Results 101 to 110 of about 104,732 (315)

CC Chemokine Receptor 5 (CCR5) Desensitization [PDF]

Journal of Biological Chemistry, 2010
CC chemokine receptor 5 (CCR5), the major HIV coreceptor, is a G protein-coupled receptor (GPCR) involved in cell activation and migration in response to chemokines. Blockade of CCR5 is an effective anti-HIV strategy, and potent anti-HIV chemokine analogs such as PSC-RANTES have been developed.
Escola, Jean-Michel, Kuenzi, Gabriel, Gaertner, Hubert François, Foti, Michelangelo, Hartley, Oliver   +4 more
openaire   +4 more sources

Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions

Scientific Reports
The chemokine receptor CCR5 is known to exist in cell surface subpopulations that differ in their capacity to engage ligands. One proposed explanation for this phenomenon is the presence of CCR5 species with different levels of post-translational ...
Inês Pinheiro, Nicolas Calo, Marianne Paolini-Bertrand, Oliver Hartley   +3 more
doaj   +1 more source

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

Advanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan, Yu‐Yun Ye, Pu Shen, Jie Zhang, Qian‐Fang Meng, Ying Chen, Xin Xu, Xuan‐Lin Zhang, Lang Rao, Zhi‐Jin Fan, Jian‐Xing He   +10 more
wiley   +1 more source

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide [PDF]

, 2004
BACKGROUND: For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission.
A Robert Neurath, A Stone, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, B Conde-Petit, C Berset, C Ma, CD Pilcher, CD Rizzuto, CW Davis, DH Schwartz, DJ Bacon, E Poyrazoglu, EA Merritt, EG Cormier, G Zhang, H Blaak, H Brown, J Moore, JM Johnson, JP Moore, L Hammar, L Wu, M Hsu, M Seguchi, MA Skinner, N DeTommasi, N Mahmood, N Mahmood, Nathan Strick, P Langley, P Suphaphiphat, P Tomasik, P Westervelt, P Westervelt, PD Kwong, PJ Kraulis, Q Hu, Q Zhao, R Pantophlet, R Shattock, R Stute, R Weiss, RJ Shattock, RJ Shattock, RN Fichorova, RN Fichorova, RS Veazey, S Garg, S Gartner, S Laal, S Liu, S-T Hsu, SH Xiang, TC Pierson, UNAIDS, VJ Tomazic-Jezic, WC Greene, WR Yao, Y Van Herrewege, Yun-Yao Li   +66 more
core   +3 more sources

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

Advanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li, Julian Aurelio Marschner, Yoshihiro Kusunoki, Ningxin Zhang, Xiaoxin Li, Hao Deng, Zhibo Zhao, Kanako Watanabe‐Kusunoki, Zhihui Zhu, Yan Xu, Stefanie Steiger, Maciej Lech, Katalin Susztak, Christian Schulz, Hans‐Joachim Anders   +14 more
wiley   +1 more source

Elevated ACKR2 expression is a common feature of inflammatory arthropathies [PDF]

, 2017
Objectives. Chemokines are essential contributors to leucocyte accumulation at sites of inflammatory pathology. Interfering with chemokine or chemokine receptor function therefore represents a plausible therapeutic option.
Baldwin, Helen M., Codullo, Veronica, Graham, Gerard J., King, Vicky, McInnes, Iain, Singh, Mark D., Wilson, Hilary   +6 more
core   +1 more source

An LCN2‐Dependent Positive‐Feedback Loop Between Gastric Cancer Cells and Tumor‐Associated‐Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis

Advanced Science, EarlyView.
In this study, the expression and function of LCN2 in GC is aimed to investigate and elucidate the mechanisms by which the LCN2‐dependent positive‐feedback loop between GC cells and TAMs drives lymphangiogenesis and lymphatic metastasis. These findings suggest that LCN2 may serve as a potential prognostic biomarker and therapeutic target in GC ...
Zhixin Huang, Ying Li, Yan Qian, Linying Ye, Tianhao Zhang, Yang Cheng, Jialin Wu, Peng Duan, Tiantian Zhang, Zihan Yu, Zeyu Zhao, Risheng Zhao, Zhi Liang, Ertao Zhai, Shirong Cai, Jianhui Chen   +15 more
wiley   +1 more source

CCR3, CCR4, CCR5, and CXCR3 expression in peripheral blood CD4+ lymphocytes in gastric cancer patients

Advanced Biomedical Research, 2013
Background: CD4+(TH1, and TH2) cell groups in the point of view of chemokine receptor expression were considered in blood of stomach cancer patients. Materials and Methods: The percentage of blood CD4+ T cells expressing chemokine receptors (before and ...
Alireza Andalib, Hassan Doulabi, Mohammad Reza Maracy, Abbas Rezaei, Seyed Javad Hasheminia   +4 more
doaj   +1 more source

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

Advanced Science, EarlyView.
This review summarizes recent advances in the spatiotemporal dynamics of the tumor microenvironment (TME). It highlights the roles of diverse immune and stromal cell populations, spatial architecture of the TME, as well as the gut and tumor microbiota in influencing responses to immune checkpoint inhibitors (ICIs), by integrating insights from single ...
Yuanyuan Zhang, Zhihua Liu
wiley   +1 more source