Results 111 to 120 of about 104,732 (315)
PLoS Genetics, 2011 Chromosome 3p21-22 harbors two clusters of chemokine receptor genes, several of which serve as major or minor coreceptors of HIV-1. Although the genetic association of CCR5 and CCR2 variants with HIV-1 pathogenesis is well known, the role of variation in
Ping An +15 more
doaj +1 more source
Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]
, 2002 Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Cannon, C.A., Hosie, M.J., Willett, B.J.
core +2 more sources
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Allergic rhinitis (AR) and asthma are involved in complex interactions between Th1 and Th2 inflammatory pathways. House dust mite (HDM) activates protease‐activated receptor 2 (PAR2) to trigger inflammatory responses, but current treatments often provide inadequate control.
Miran Kang +8 more
wiley +1 more source
Evidence for CD4-enchanced Signaling through the Chemokine Receptor CCR5 [PDF]
Journal of Biological Chemistry, 2003 The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes, but the physiological role of this interaction has not been elucidated. Here we show that detergent-solubilized, purified CCR5 can directly associate with purified soluble fragments of the extracellular portion of CD4.
Xiahong Wang +6 more
openaire +3 more sources
The Expanding Therapeutic Perspective of CCR5 Blockade
Frontiers in Immunology, 2018 CCR5 and its interaction with chemokine ligands have been crucial for understanding and tackling HIV-1 entry into target cells. However, over time, CCR5 has witnessed an impressive transition from being considered rather unimportant in physiology and ...
Luca Vangelista, Sandro Vento
doaj +1 more source
Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members. [PDF]
, 2019 HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Coskun, Ayse K +12 more
core
Genetic and epigenetic regulation of CCR5 transcription [PDF]
, 2012 biolog
Carrington +15 more
core +5 more sources
Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang +5 more
wiley +1 more source
Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5
, 2023 AbstractBy driving monocyte chemotaxis, the chemokine receptor CCR2 shapes inflammatory responses and the formation of tumor microenvironments. This makes it a promising target in inflammation and immuno-oncology; however, despite extensive efforts, there are no FDA-approved CCR2-targeting therapeutics.
John R.D. Dawson +10 more
openaire +2 more sources
CCL5 rs2107538 Polymorphism Increased the Risk of Tuberculosis in a Sample of Iranian Population
Prague Medical Report, 2016 Cysteine-cysteine chemokine ligand 5 (CCL5) with immunoregulatory and inflammatory activities has an important role in granuloma formations that activates and stimulates T-cells and macrophages.
Hamid Reza Kouhpayeh +5 more
doaj +1 more source