Results 121 to 130 of about 104,732 (315)

HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]

, 2012
HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Alvarez M, Batmanian J, Bocharov G, Brennan CA, Burgard M, Buzon MJ, Dahl V, Dai L, Domingo E, Duarte EA, Etienne L, Fang G, Fultz PN, Gunthard HF, Henriet S, Iordanskiy S, Josef Eberle, Julg B, Kijak GH, Korber B, Law M, Lemey P, Lorenzo-Redondo R, Lutz G. Gürtler, Motomura K, Neel C, Onafuwa-Nuga A, Pathak VK, Pathak VK, Rachinger A, Sauter D, Shimizu N, Simon-Loriere E, Smith DM, Sterjovski J, Swenson LC, Tienen C, Troyer JL, Van der Kuyl AC, Van der Vlist M, Zhu T   +40 more
core   +1 more source

Mucosal‐Associated Invariant T Cells in Rheumatic Diseases

Arthritis &Rheumatology, EarlyView.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Absence of Association between CCR5 rs333 Polymorphism and Childhood Acute Lymphoblastic Leukemia

Advances in Hematology, 2014
Acute lymphoblastic leukemia (ALL) is a malignant disorder that originates from one single hematopoietic precursor committed to B- or T-cell lineage. Ordinarily, these cells express CCR5 chemokine receptor, which directs the immune response to a cellular
Carlos Eduardo Coral de Oliveira, Marla Karine Amarante, Aparecida de Lourdes Perim, Patricia Midori Murobushi Ozawa, Carlos Hiroki, Glauco Akelinghton Freire Vitiello, Roberta Losi Guembarovski, Maria Angelica Ehara Watanabe   +7 more
doaj   +1 more source

Epidermal Interferon kappa drives cutaneous lupus‐like lesions, photosensitivity and systemic autoimmunity in vivo

Arthritis &Rheumatology, Accepted Article.
Objective Keratinocyte‐derived interferon kappa (IFN‐κ) is chronically overexpressed in human non‐lesional systemic lupus erythematosus (SLE) skin. Recent evidence suggests that epidermal signals instruct the immune system in SLE, but whether epidermal IFN‐κ alone is sufficient to drive lupus phenotypes has not been investigated.
Benjamin Klein, Deborah J. Colesa, Yiqing Gao, Patrick A. O'Brien, Lin Zhang, Lori Lowe, Kelsey E. McNeely, Nguyen Thi Kim Nguyen, Svenja Henning, Mehrnaz Gharaee‐Kermani, Jeffrey B. Hodgin, Jacob W. S. Martens, Johann E. Gudjonsson, Celine C. Berthier, J. Michelle Kahlenberg   +14 more
wiley   +1 more source

Host factors and early treatments to restrict paediatric HIV infection and early disease progression [PDF]

, 2015
open6noA body of evidence indicates that a threshold level of the virus is required to establish systemic and persistent HIV infection in the host and that this level depends on virus-host interactions.
De Rossi, Anita, Freguja, Riccardo, Gianesin, Ketty, Giaquinto, Carlo, Petrara, Raffaella, Zanchetta, Marisa   +5 more
core   +1 more source

Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome.

A M A Archives of Ophthalmology, 2006
OBJECTIVE To characterize chemokine receptor CCR5 expression on the conjunctival epithelium in dry eye syndromes. METHODS Conjunctival impression cytology samples were obtained from normal subjects (n = 15) and patients with dry eye syndrome (n = 45 ...
A. Gulati, M. Sacchetti, S. Bonini, R. Dana   +3 more
semanticscholar   +1 more source

CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. [PDF]

, 2019
Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these ...
Anderson, Stephen K, Carrington, Mary, Chowdhury, Fatema Z, Deeks, Steven G, Ewy, Rodger, Gatanaga, Hiroyuki, Goedert, James J, Haas, David W, Hoots, W Keith, Kirk, Gregory D, Kulkarni, Smita, Kulkarni, Viraj, Le Gall, Sylvie, Lied, Alexandra, Lin, Zhansong, Margolick, Joseph, Martin, Maureen P, McLaren, Paul J, Michael, Nelson, Naranbhai, Vivek, Nguyen, Hoang, Oka, Shinichi, Rucevic, Marijana, Singh, Sukhvinder, Takiguchi, Masafumi, Thio, Chloe L, Viard, Mathias, Walker, Bruce, Walker-Sperling, Victoria, Yu, Xu G, Zou, Chengcheng   +30 more
core  

Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin α\(_4\)β\(_7\) [PDF]

, 2009
Background: The Step Study was a randomized trial to reduce HIV infection through vaccination with an adenovirus type 5-based gag/pol/nef construct; analysis following early cessation of the trial revealed an excess of HIV seroconversion in Ad5 ...
Chakupurakal, Geothy, Cobbold, Mark, Mautner, Vivien, Moss, Paul AH, Onion, David   +4 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Maraviroc: a review of its use in HIV infection and beyond

Drug Design, Development and Therapy, 2015
Shawna M Woollard, Georgette D Kanmogne Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA Abstract: The human immunodeficiency virus-1 (HIV-1) enters target cells by binding its envelope ...
Woollard SM, Kanmogne GD
doaj