Results 131 to 140 of about 104,732 (315)

Selective recruitment of CXCR3+ and CCR5+ CCR4+ T cells into synovial tissue in patients with rheumatoid arthritis. [PDF]

, 2006
The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon gamma-producing Th1-type CD4+ T cells.
Iwahashi, Mitsuhiro, Makino, Hirofumi, Norii, Mika, Ueno, Akiko, Yamamura, Masahiro, Yamana, Jiro   +5 more
core   +1 more source

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

CCR5: Established paradigms and new frontiers for a ‘celebrity’ chemokine receptor

Cytokine, 2018
Because of the level of attention it received due to its role as the principal HIV coreceptor, CCR5 has been described as a 'celebrity' chemokine receptor. Here we describe the development of CCR5 inhibitory strategies that have been developed for HIV therapy and which are now additionally being considered for use in HIV prevention and cure. The wealth
Scurci, Ilaria, Martins, Elsa, Hartley, Oliver   +2 more
openaire   +5 more sources

The Chemokine Receptor CCR5, a Therapeutic Target for HIV/AIDS Antagonists, Is Critical for Recovery in a Mouse Model of Japanese Encephalitis

PLoS ONE, 2012
Japanese encephalitis is a severe central nervous system (CNS) inflammatory disease caused by the mosquito-borne flavivirus, Japanese encephalitis virus (JEV).
Maximilian Larena, M. Regner, M. Lobigs
semanticscholar   +1 more source

Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten‐Induced Cytotoxicity and Inflammation

Molecular Nutrition &Food Research, EarlyView.
Celiac disease (CD) is triggered by gluten in genetically predisposed individuals and is mainly treated with a gluten‐free diet. However, symptoms may persist. This review explores how certain Bifidobacterium strains may reduce inflammation and gluten toxicity through six mechanisms, including modulation of immune responses and gut microbiota.
Taynara Cipriano Scherer, Ivan De Marco, Natália Regina Coldebella Ferreira, Tatiana Colombo Pimentel, Marciane Magnani, Guilherme de Souza Hassemer, Amanda Bagolin do Nascimento, Silvani Verruck   +7 more
wiley   +1 more source

MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis [PDF]

, 2016
Objectives: To test the hypothesis that miR-155 regulates monocyte migratory potential via modulation of chemokine and chemokine receptor expression in rheumatoid arthritis (RA); and thereby is associated with disease activity.
Elmesmari, Aziza, Fraser, Alasdair R., Gilchrist, Derek, Kurowska-Stolarska, Mariola, McInnes, Iain B., McSharry, Charles, Stewart, Lynn, Vaughan, Diane, Wood, Claire   +8 more
core   +1 more source

Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist.

Organic Letters, 2007
The total synthesis of anibamine, the first and only natural product known as a chemokine receptor CCR5 antagonist, is reported herein. Anibamine was synthesized from acetylacetone and cyanoacetamide in 10 steps.
Guo Li, K. Watson, R. Buckheit, Yan Zhang   +3 more
semanticscholar   +1 more source

CCR5 predicts neurotoxicity in CAR‐T‐cell therapy

British Journal of Haematology, EarlyView.
Patients undergoing chimeric antigen receptor T (CAR T)‐cell therapy are at risk of developing immune effector cell‐associated neurotoxicity syndrome (ICANS). We observed an upregulation of CCR5 and CCR2 expression in CD4+ T cells among patients who developed ICANS.
Ayal Rozenberg, Shahar Shelly, Raz Winer, Riva Fineman, Shani Haller, Shimrit Ringelstein‐Harlev, Israel Henig, Dana Yehudai‐Ofir, Tsila Zuckerman, Tamar Tadmor, Reut Harel, Esther Ganelin‐Cohen, Ofrat Beyar‐Katz   +12 more
wiley   +1 more source

Polymorphism of CC chemokine receptors CCR2 and CCR5 in Crohn's disease

Immunology Letters, 2001
Crohn's disease (CD) is a chronic inflammatory disease of the intestine that is characterized by mononuclear cell infiltration and a predominant Th1 lymphocyte response. We tested the hypothesis that CC chemokine receptors CCR2 and CCR5 might be important in the regulation of the intestinal immune response in this disease, and we speculated that ...
Herfarth, H., Pollok-Kopp, B., Goke, M., Press, A., Oppermann, Martin   +4 more
openaire   +4 more sources