Results 141 to 150 of about 48,525 (279)

The role of CCR5 in HCV infection

European Journal of Medical Research, 2010
Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critically involved in these processes.
Coenen Martin, Nattermann Jacob
doaj   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans

Immunology &Cell Biology, Volume 104, Issue 2, Page 109-124, February 2026.
In this study, we characterize a distinct subpopulation of undifferentiated invariant natural killer T (iNKT) cells in the peripheral blood of healthy adults, which are characterized by CD38 expression in a resting state. This CD38+ subset closely resembles iNKT cells from cord blood and thymus, exhibiting a unique cytokine profile and alterations in ...
Christopher Menne, Naeimeh Tavakolinia, Louis Perriman, Wiebke Moskorz, Christine Cosmovici, Andreas Walker, Lara Olejnik, Katharina Raba, Mei RM Du, Fernando J Rossello, Igor E Konstantinov, Stuart P Berzins, Daniel G Pellicci, Jörg Timm   +13 more
wiley   +1 more source

Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding [PDF]

, 1997
Lijun Wu, Greg LaRosa, Nasim Kassam, Cynthia J. Gordon, Heidi Heath, Nancy Ruffing, Howard Chen, Jason Humblias, Michel Samson, Marc Parmentier, John P. Moore, Charles R. Mackay   +11 more
openalex   +1 more source

Asymmetric Catalytic Hydrogenation toward a Value‐Added Chiral Building Block: Optically Active γ‐Butyrolactone Scaffold from Renewable and Synthetic Derived Feedstocks

European Journal of Organic Chemistry, Volume 29, Issue 3, January 22, 2026.
This brief compendium summarizes the most successful asymmetric hydrogenation strategies for the preparation of chiral monocyclic γ‐lactone derivatives from keto acids and keto esters, with emphasis on their relevance for large‐scale production and high enatioselectivities. This article provides a brief compendium on the production of chiral monocyclic
Marta Feliz, Maria J. Sabater
wiley   +1 more source

Genetic variants linked to T2DM risk in Kurdish populations

Diabetes, Metabolic Syndrome and Obesity, 2019
Shadi Golsheh,1 Fatemeh Keshavarzi21Department of Biology, Kurdistan Science and Research Branch, Islamic Azad University, Sanandaj, Iran; 2Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, IranBackground: The polymorphisms of ...
Golsheh S, Keshavarzi F
doaj  

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source

CC Chemokine Receptor 5 (CCR5) Desensitization [PDF]

Journal of Biological Chemistry, 2010
Jean-Michel Escola, Gabriel Kuenzi, Hubert Gaertner, Michelangelo Foti, Oliver Hartley   +4 more
openaire   +1 more source

The chemokines CCL5 and CXCL12 exhibit high‐affinity binding to N‐terminal peptides of the non‐cognate receptors CXCR4 and CCR5 , respectively [PDF]

, 2023
Naama Kessler, Sabine R. Akabayov, Leah Cohen, Tali Scherf, Fred Naider, Jacob Anglister   +5 more
openalex   +1 more source

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source