Results 141 to 150 of about 104,732 (315)

Therapeutic Perspectives of HIV-Associated Chemokine Receptor (CCR5 and CXCR4) Antagonists in Carcinomas. [PDF]

Int J Mol Sci, 2022
González-Arriagada WA, García IE, Martínez-Flores R, Morales-Pison S, Coletta RD.   +4 more
europepmc   +1 more source

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
core   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

The role of cholesterol and sphingolipids in chemokine receptor function and HIV-1 envelope glycoprotein-mediated fusion

Virology Journal, 2006
Background HIV-1 entry into cells is a multifaceted process involving target cell CD4 and the chemokine receptors, CXCR4 or CCR5. The lipid composition of the host cell plays a significant role in the HIV fusion process as it orchestrates the appropriate
Puri Anu, Wang Ji, Viard Mathias, Rawat Satinder S, Ablan Sherimay, Blumenthal Robert   +5 more
doaj   +1 more source

The Chemokine Receptor CCR5 Links Memory CD4⁺ T Cell Metabolism to T Cell Antigen Receptor Nanoclustering. [PDF]

Front Immunol, 2021
Blanco R, Gómez de Cedrón M, Gámez-Reche L, Martín-Leal A, González-Martín A, Lacalle RA, Ramírez de Molina A, Mañes S.   +7 more
europepmc   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

European Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano, Emmanuel Somm, François R. Jornayvaz, Nicolas Vuilleumier   +3 more
wiley   +1 more source

Frequency of CCR5?32 Variant in North-West of Iran [PDF]

Journal of Sciences, Islamic Republic of Iran, 2009
Chemokine and chemokine receptors show several variations which may affect resistance to infectious disease. A 32 base pair deletion in the open reading frame of the human CCR5 gene (CCR5?32) results in producing a truncated antigen which fails to be ...
D. Omrani
doaj  

Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity. [PDF]

Int Immunopharmacol, 2021
Cuesta-Llavona E, Gómez J, Albaiceta GM, Amado-Rodríguez L, García-Clemente M, Gutiérrez-Rodríguez J, López-Alonso I, Hermida T, Enríquez AI, Hernández-González C, Gil-Peña H, Domínguez-Garrido E, Pérez-Oliveira S, Alvarez V, López-Larrea C, Suarez-Alvarez B, Tranche S, Jimeno-Demuth FJ, Coto E.   +18 more
europepmc   +1 more source

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. [PDF]

, 1998
Suofu Qin, James B. Rottman, Patricia N. Myers, Nasim Kassam, Michael E. Weinblatt, Marcel Loetscher, A E Koch, Bernhard Moser, Charles R. Mackay   +8 more
openalex   +1 more source