Results 151 to 160 of about 104,732 (315)

Tertiary Lymphoid Structures Predict Prognosis and Immune Checkpoint Inhibitor Efficacy in Lung Squamous Cell Carcinoma

Immunology, EarlyView.
This study demonstrates that the presence, high density and maturity of TLSs in LUSC patients are strongly associated with significantly improved overall survival. TLS+ was an independent positive prognostic factor and predicted better outcomes even for patients receiving immunotherapy.
Kuifei Chen, Suna Zhou, Pin Zhou, Zhenwei Sun, Yixiu Xu, Ziran Chen, Liangmin Zhang, Wenhu Pi, Meifu Gan, Haihua Yang   +9 more
wiley   +1 more source

The role of CCR5 in HCV infection

European Journal of Medical Research, 2010
Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critically involved in these processes.
Coenen Martin, Nattermann Jacob
doaj   +1 more source

Hepatic Inflammation and Liver Injury in a Model of Bacterial Infection Triggered Acute‐on‐Chronic Liver Injury

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Acute‐on‐chronic liver failure (ACLF) is characterized by acute decompensation of chronic liver disease in the presence of an acute trigger, and bacterial infection (BI) is the most common trigger of ACLF. Therefore, we aimed to establish a mouse model that mimics bacterial infection‐related acute‐on‐chronic liver failure ...
S. C. Karatayli, S. N. Weber, R. A. Hall, M. Hohl, L. Kaps, J. M. Schattenberg, F. Lammert, E. Karatayli   +7 more
wiley   +1 more source

Triplex targeting of a native gene in permeabilized intact cells: covalent modification of the gene for the chemokine receptor CCR5 [PDF]

, 1998
Evgeniy Belousov
openalex   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

Molecular Therapy: Nucleic Acids, 2015
The chemokine (C-C motif) receptor 5 (CCR5) serves as an HIV-1 co-receptor and is essential for cell infection with CCR5-tropic viruses. Loss of functional receptor protects against HIV infection.
HyunJun Kang, Petra Minder, Mi Ae Park, Walatta-Tseyon Mesquitta, Bruce E Torbett, Igor I Slukvin   +5 more
doaj   +1 more source

Genetic variants linked to T2DM risk in Kurdish populations

Diabetes, Metabolic Syndrome and Obesity, 2019
Shadi Golsheh,1 Fatemeh Keshavarzi21Department of Biology, Kurdistan Science and Research Branch, Islamic Azad University, Sanandaj, Iran; 2Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, IranBackground: The polymorphisms of ...
Golsheh S, Keshavarzi F
doaj  

Pulsed high-dose dexamethasone modulates Th1-/Th2-chemokine imbalance in immune thrombocytopenia

Journal of Translational Medicine, 2016
Background Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear.
Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou, Chengshan Guo   +7 more
doaj   +1 more source

Gene Organization and Promoter Function for CC Chemokine Receptor 5 (CCR5) [PDF]

, 1998
Florence Guignard, Christophe Combadière, H. Lee Tiffany, Philip M. Murphy   +3 more
openalex   +1 more source

A Mathematical Model for Allergic Reactions Induced by the Therapy of HIV

Mathematical Methods in the Applied Sciences, Volume 48, Issue 14, Page 13816-13838, 30 September 2025.
ABSTRACT A new mathematical model for cell evolution in HIV is introduced and studied. Delay differential equations are used to capture the dynamics of immune system cells involved in allergies, as well as the evolution of HIV viruses, infected and uninfected CD4 +$$ {}^{+} $$ cells, and cytotoxic T‐lymphocytes, under specific antiretroviral therapy ...
Rawan Abdullah, Florin Avram, Andrei Halanay, Rodica Radulescu   +3 more
wiley   +1 more source