Results 161 to 170 of about 104,732 (315)

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, Volume 15, Issue 9, Page 1436-1458, September 2025.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Characterization of the longitudinal HIV-1 quasispecies evolution in HIV-1 infected individuals co-infected with Mycobacterium tuberculosis [PDF]

, 2010
One of the earliest and most striking observations made about HIV is the extensive genetic variation that the virus has within individual hosts, particularly in the hypervariable regions of the env gene which is divided into 5 variable regions (V1-V5 ...
Leulebirhan, Tsigereda Biru
core  

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

Go for Gold: Development of a Scalable Synthesis of [1‐(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors

ChemistryOpen, Volume 14, Issue 9, September 2025.
[1‐(Ethoxycarbonyl)cyclopropyl] triphenylphosphonium tetrafluoroborate is a limiting key reagent for synthesis of the tricyclic 5,6‐dihydropyrimido[5,4‐e]indolizine and related scaffolds, which are central to First‐in‐Class covalent inhibitors of the protein kinase monopolar spindle 1/threonine tyrosine kinase (TTK).
Leon Rebhan, Rebekka Fürst, Dieter Schollmeyer, Ricardo A. M. Serafim, Matthias Gehringer   +4 more
wiley   +1 more source

Natural Proteolytic Processing of Hemofiltrate Cc Chemokine 1 Generates a Potent Cc Chemokine Receptor (Ccr)1 and Ccr5 Agonist with Anti-HIV Properties [PDF]

, 2000
Michel Detheux, Ludger Ständker, Jalal Vakili, Jan Münch, Ulf Forssmann, Knut Adermann, Stefan Pöhlmann, Gilbert Vassart, Frank Kirchhoff, Marc Parmentier, Wolf‐Georg Forssmann   +10 more
openalex   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

The Puzzling Role of CXCR4 in Human Immunodeficiency Virus Infection

Theranostics, 2013
The human immunodeficiency virus type-1 (HIV-1) is the etiological agent of the acquired immunodeficiency syndrome (AIDS), a disease highly lethal in the absence of combination antiretroviral therapy. HIV infects CD4+ cells of the immune system (T cells,
Elisa Vicenzi, Pietro Liò, Guido Poli
doaj  

Tissue‐Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells

Immunological Reviews, Volume 334, Issue 1, September 2025.
ABSTRACT Humoral immune responses are critical for protection against immune challenge by pathogens and transformed cells, while dysregulated antibody production is a hallmark of autoimmune diseases. T follicular helper (Tfh) cells are central to the development of humoral immunity, regulating B‐cell maturation, including immunoglobulin class switch ...
Shuting Chen, Joseph Craft
wiley   +1 more source

Up‐regulation of β‐chemokines and down‐modulation of CCR5 co‐receptors inhibit simian immunodeficiency virus transmission in non‐human primates [PDF]

, 2000
T Lehner, Y. Wang, Martin Cranage, Louisa Tao, Elaine Mitchell, Christopher A. Bravery, Carl Doyle, Karen R. Pratt, G.A. Hall, Michael J. Dennis, L. Villinger, Lesley A. Bergmeier   +11 more
openalex   +1 more source

Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity

Antimicrobial Agents and Chemotherapy, 2005
P. Dorr, M. Westby, Susan Dobbs, P. Griffin, B. Irvine, M. Macartney, J. Mori, G. Rickett, C. Smith-Burchnell, C. Napier, R. Webster, D. Armour, David A. Price, B. Stammen, A. Wood, M. Perros   +15 more
semanticscholar   +1 more source