Pharmacological characterization of the chemokine receptor, CCR5 [PDF]
British Journal of Pharmacology, 2002 We investigated the effects of a number of naturally occurring chemokines (MIP‐1α, MIP‐1β, RANTES, MCP‐2, MCP‐3, MCP‐4) on different processes linked to the chemokine receptor CCR5 in recombinant CHO cells expressing the receptor at different levels.
A. Mueller +4 more
semanticscholar +7 more sources
Expression of the chemokine receptor CCR5 in psoriasis and results of a randomized placebo controlled trial with a CCR5 inhibitor [PDF]
Archives of Dermatological Research, 2007 Several reports have indicated that the chemokine receptor CCR5 and its ligands, especially CCL5 (formerly known as RANTES), may play a role in the pathogenesis of psoriasis. The purpose of this investigation was to examine the expression of CCR5 and its
M. de Groot +10 more
semanticscholar +2 more sources
Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK. [PDF]
Blood, 1998 R. Ganju +6 more
semanticscholar +2 more sources
The GHS-R Blocker D-[Lys3] GHRP-6 Serves as CCR5 Chemokine Receptor Antagonist [PDF]
International Journal of Medical Sciences, 2012 [D-Lys3]-Growth Hormone Releasing Peptide-6 (DLS) is widely utilized in vivo and in vitro as a selective ghrelin receptor (GHS-R) antagonist. This antagonist is one of the most common antagonists utilized in vivo to block GHS-R function and activity ...
Kalpesh Patel, Vishwa Deep Dixit, Jun Ho Lee, Jie Wan Kim, Eric M. Schaffer, Dzung Nguyen, Dennis D. Taub
doaj +2 more sources
The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5) [PDF]
Cells, 2020 (1) Background: Extracellular nicotinamide phosphoribosyltrasferase (eNAMPT) is released by various cell types with pro-tumoral and pro-inflammatory properties.
Simone Torretta +6 more
doaj +2 more sources
Chemokine receptor CCR5: from AIDS to atherosclerosis [PDF]
British Journal of Pharmacology, 2011 There is increasing recognition of an important contribution of chemokines and their receptors in the pathology of atherosclerosis and related cardiovascular disease. The chemokine receptor CCR5 was initially known for its role as a co‐receptor for HIV infection of macrophages and is the target of the recently approved CCR5 antagonist maraviroc ...
Kl Jones, J. Maguire, A. Davenport
semanticscholar +4 more sources
Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic. [PDF]
Journal of Infectious Diseases, 2008 Jean K. Lim +7 more
semanticscholar +2 more sources
Chemokine receptor CCR5 antagonist maraviroc: medicinal chemistry and clinical applications. [PDF]
Curr Top Med Chem, 2014 Xu GG, Guo J, Wu Y.
europepmc +2 more sources
pH‐Independent Endocytic Cycling of the Chemokine Receptor CCR5 [PDF]
Traffic, 2004 Following agonist activation, the chemokine receptor CCR5 is internalised through clathrin‐coated pits and delivered to recycling endosomes. Subsequently, ligand‐ free and resensitised receptors are recycled to the cell surface. Currently little is known of the mechanisms regulating resensitisation and recycling of this G‐protein coupled receptor. Here
Nathalie Signoret +3 more
openalex +5 more sources
Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis [PDF]
Annals of the Rheumatic Diseases, 2004 V. Pokorny +7 more
semanticscholar +2 more sources