In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases [PDF]
Mediators of Inflammation, 2003 Background: CC chemokine ligand (CCL)5 and its receptor CCR5 contribute to leukocyte migration into lungs of patients with diffuse lung diseases (DLD). Pharmacological regulation of CCL5 and CCR5 expression was therefore explored in bronchoalveolar cells
Veronika Sekerova +6 more
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Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins. [PDF]
Cell Commun SignalBackground CCR5 is a critical receptor for anti-infectious immunity. It acts by binding chemokines, which activate Gαβγ protein-dependent signaling and ultimately regulate leukocyte recruitment.
Gasser R +9 more
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The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications. [PDF]
BiomedicinesNeuropathic pain, a chronic condition arising from injury or dysfunction of the somatosensory nervous system, is characterized by persistent hypersensitivity and spontaneous pain.
García-Domínguez M.
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CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway [PDF]
Journal of Inflammation, 2009 Background Herpesviruses have evolved chemokines and chemokine receptors, which modulate the recruitment of human leukocytes during the inflammatory response to infection.
Julie Catusse +2 more
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Filling the Gaps in Antagonist CCR5 Binding, a Retrospective and Perspective Analysis
Frontiers in Immunology, 2022 The large number of pathologies that position CCR5 as a central molecular determinant substantiates the studies aimed at understanding receptor-ligand interactions, as well as the development of compounds that efficiently block this receptor.
Yerkezhan Amerzhanova, Luca Vangelista
doaj +1 more source
Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization. [PDF]
PLoS ONE, 2012 Chemokine receptors are members of the G protein-coupled receptor (GPCR) family. CCR5 and CXCR4 act as co-receptors for human immunodeficiency virus (HIV) and several efforts have been made to develop ligands to inhibit HIV infection by blocking those ...
Yi-Qun Kuang +6 more
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Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) [PDF]
Journal of Leukocyte Biology, 1999 Abstract The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1á (MIP-1á), MIP-1β, and amino-terminal modifications of RANTES (Met ...
H, Olbrich, A E, Proudfoot, M, Oppermann
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Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
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Chemokine receptor CCR5: from AIDS to atherosclerosis [PDF]
British Journal of Pharmacology, 2011 There is increasing recognition of an important contribution of chemokines and their receptors in the pathology of atherosclerosis and related cardiovascular disease. The chemokine receptor CCR5 was initially known for its role as a co‐receptor for HIV infection of macrophages and is the target of the recently approved CCR5 antagonist maraviroc ...
K L, Jones, J J, Maguire, A P, Davenport
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Pharmacological characterization of the chemokine receptor, CCR5 [PDF]
British Journal of Pharmacology, 2002 We investigated the effects of a number of naturally occurring chemokines (MIP‐1α, MIP‐1β, RANTES, MCP‐2, MCP‐3, MCP‐4) on different processes linked to the chemokine receptor CCR5 in recombinant CHO cells expressing the receptor at different levels.
Mueller, Anja +4 more
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