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Control of antigen-independent T-cell migration after HSCT. [PDF]
Blood AdvKoyama M.
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Pathways for internalization and recycling of the chemokine receptor CCR5.
Blood, 2002AbstractM-tropic human immunodeficiency virus (HIV-1) strains enter the cell after interaction with their receptors, CD4 and the G-protein–coupled chemokine receptor CCR5. The number of cell surface CCR5 molecules is thought to be important in determining the infection rate for HIV. Cell surface CCR5 is dependent on the rate of receptor internalization
A. Mueller, E. Kelly, P. Strange
semanticscholar +5 more sources
Chemokine receptor CCR5: insights into structure, function, and regulation.
Cellular Signalling, 2004 CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells. It also serves as the main coreceptor for the entry of R5 strains of human immunodeficiency virus (HIV-1, HIV-2).
M. Oppermann
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The International Journal of Biochemistry & Cell Biology, 2004
The chemokine receptor, CCR5, is a G protein coupled receptor responsible for some of the effects of the chemokines CCL3, CCL4 and CCL5. It is also one of the co-receptors for the entry of human immunodeficiency virus-1 (HIV-1) into cells. Regulation of CCR5 number on cells is, therefore, important for determining the infection rate by HIV-1.
Mueller, A., Strange, P. G.
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The chemokine receptor, CCR5, is a G protein coupled receptor responsible for some of the effects of the chemokines CCL3, CCL4 and CCL5. It is also one of the co-receptors for the entry of human immunodeficiency virus-1 (HIV-1) into cells. Regulation of CCR5 number on cells is, therefore, important for determining the infection rate by HIV-1.
Mueller, A., Strange, P. G.
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The chemokine receptor CCR5 in the central nervous system
Progress in Neurobiology, 2011The expression and the role of the chemokine receptor CCR5 have been mainly studied in the context of HIV infection. However, this protein is also expressed in the brain, where it can be crucial in determining the outcome in response to different insults.
Renier Myburgh +4 more
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Polymorphisms in CCR5 chemokine receptor gene in Japan
International Journal of Immunogenetics, 2007SummaryMutations in the human CC chemokine receptor 5 (CCR5) gene may alter the expression or function of the protein product, thereby altering chemokine binding/signalling or human immunodeficiency virus type 1 (HIV‐1) infection of the cells that normally express CCR5 protein.
Chantapong Wasi +8 more
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Interaction of soluble CD4 with the chemokine receptor CCR5
Biochemical and Biophysical Research Communications, 2003The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes. The CD4-CCR5 complex exhibits distinct binding properties for macrophage inflammatory protein 1beta (MIP-1beta) and enhanced G-protein signaling as compared with those of CCR5 alone.
Robert Staudinger +2 more
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Small Molecule Antagonists of the Chemokine Receptor CCR5
Current Topics in Medicinal Chemistry, 2010This review will focus on the discovery and clinical development of small molecule antagonists of CCR5 for the treatment of HIV-1/AIDS, as well as for the potential treatment of inflammatory diseases. In particular, we will focus on the specific medicinal chemistry problems that were faced during the discovery of the molecules.
Remy Lemoine, Jutta Wanner
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Isolation and Structure of Antagonists of Chemokine Receptor (CCR5)
Journal of Natural Products, 2004Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this binding by a small molecule receptor antagonist could lead to a new mode of action agent for HIV-1 and AIDS. Screening of natural product extracts led to the identification of anibamine (1), a novel
S J Siciliano +14 more
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