Results 271 to 280 of about 104,732 (315)
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Chemokine receptor CCR5: polymorphism at protein level
Biochemical and Biophysical Research Communications, 2002Polymorphisms in chemokine receptor CCR5 genes have been implicated in HIV disease progression, resistance, or non-progressive infection. Multiple CCR5 transcripts and mRNA diversity have also been identified. This study presents evidence to show that two distinct forms of CCR5 protein, 62 and 42k Da, are present in human lymphocytic cells and monkey ...
Tomoko Miyagi +5 more
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Diverse signalling by different chemokines through the chemokine receptor CCR5
Biochemical Pharmacology, 2006We have investigated the signalling properties of the chemokine receptor, CCR5, using several assays for agonism: stimulation of changes in intracellular Ca(2+) or CCR5 internalisation in CHO cells expressing CCR5 or stimulation of [(35)S]GTPgammaS binding in membranes of CHO cells expressing CCR5.
Mueller, A. +2 more
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A Hammerhead Ribozyme Targeted to the Human Chemokine Receptor CCR5
Biochemical and Biophysical Research Communications, 1998The CCR5 chemokine receptor plays a crucial role in the initiation of in vivo HIV infection, acting as a critical coreceptor molecule for primary strains. Individuals with mutations in the CCR5 gene that reduce its level of expression are resistant to HIV-1 infection.
Fernando Serrano +5 more
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Allosteric effects of antagonists on signalling by the chemokine receptor CCR5
Biochemical Pharmacology, 2007Antagonists of the chemokine receptor, CCR5, may provide important new drugs for the treatment of HIV-1. In this study we have examined the mechanism of action of two functional antagonists of the chemokine receptor CCR5 (UK-396,794, UK-438,235) in signalling and internalisation assays using CHO cells expressing CCR5. Both compounds were potent inverse
Pat Dorr +4 more
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Chemokine receptor CCR5 polymorphisms and Chagas’ disease cardiomyopathy
Tissue Antigens, 2001Abstract: In this study we investigated the possible role of two CCR5 gene polymorphisms, CCR5Δ32 deletion and CCR5 59029 A→G promoter point mutation, in determining the susceptibility to Trypanosoma cruzi infection as well as in the development of chagasic heart disease.
Y. Beraún +3 more
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Soluble chemokine CCR5 receptor is present in human plasma
Immunology Letters, 2005In view of the natural resistance to infection by HIV and occasional delayed clinical manifestation of the disease, as also the fact that the virus is able to enter only cells that express CD4 and a co-receptor, we initiated a search for a soluble co-receptor that might compete with its membrane counterpart.
Alexander Kalinkovich +2 more
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Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages
Cellular Immunology, 2004Hypoxia, a decrease in oxygen tension occurring in pathological tissues, has a profound effect on macrophage functions. Here, we provide the first evidence that hypoxia inhibits CCR5 chemokine receptor expression in mouse macrophages. CCR5 was constitutively expressed in macrophages and upregulated by IFNgamma.
Maria Carla Bosco +3 more
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Clinical studies with chemokine receptor-5 (CCR5)-inhibitors
Current Opinion in HIV and AIDS, 2012To summarise recently published clinical studies of chemokine receptor-5 (CCR5)-blockers, including the small-molecule blocker, maraviroc (MVC) and CCR5-monoclonal antibodies for HIV. MVC may have immunomodulating properties through CCR5-blockade. MVC appears well tolerated and penetrates the central nervous system.
Sarah Pett, Christoph Boesecke
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CCR5 Chemokine Receptors: Gatekeepers of HIV-1 Infection
Current Drug Target -Infectious Disorders, 2002With the discovery that CCR5 is the critical protein required for infection by M-tropic HIV, has come huge research efforts, both in academia and industry, to try to exploit this finding. Thus, research advances in the fields of virology, structural protein chemistry, and receptor pharmacology have combined to add a new understanding to the process of ...
Terry P. Kenakin +4 more
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