Results 21 to 30 of about 48,525 (279)
CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. [PDF]
PLoS Pathogens, 2006 The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired ...
Imtiaz A Khan +7 more
doaj +1 more source
Cholesterol impacts chemokine CCR5 receptor ligand‐binding activity [PDF]
The FEBS Journal, 2019 The chemokine CCR5 receptor is target of maraviroc, a negative allosteric modulator of CCR5 that blocks the HIV protein gp120 from associating with the receptor, thereby inhibiting virus cellular entry. As noted with other G‐protein‐coupled receptor family members, the role of the lipid environment in CCR5 signaling remains obscure and very modestly ...
Calmet, Pierre +10 more
openaire +2 more sources
Potent Anti-HIV Chemokine Analogs Direct Post-Endocytic Sorting of CCR5. [PDF]
PLoS ONE, 2015 G protein-coupled receptors (GPCRs) are desensitized and internalized following activation. They are then subjected to post-endocytic sorting (degradation, slow recycling or fast recycling).
Claudia Bönsch +4 more
doaj +1 more source
PLoS ONE, 2022 CC Chemokine receptor 5 (CCR5), a member of the Superfamily of G Protein-Coupled Receptors (GPCRs), is an important effector in multiple physiopathological processes such as inflammatory and infectious entities, including central nervous system ...
Guillermo Goode-Romero, Laura Dominguez
doaj +1 more source
The Role and Therapeutic Targeting of CCR5 in Breast Cancer
Cells, 2023 The G-protein-coupled receptor C-C chemokine receptor 5 (CCR5) functions as a co-receptor for the entry of HIV into immune cells. CCR5 binds promiscuously to a diverse array of ligands initiating cell signaling that includes guided migration.
Rasha Hamid +7 more
doaj +1 more source
Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine–CCR5 interactions [PDF]
Antiviral Therapy, 2009 Background This study aimed to examine how CC chemokine receptor 5 (CCR5) inhibitors (aplaviroc [APL], TAK779 and maraviroc [MVC]) interact with CCR5 and affect its dynamics and physiological CC-chemokine–CCR5 interactions. Methods A yellow fluorescent protein (YFP)-tagged CCR5-expressing U373-MAGI cell line was generated and a stable CCR5-expressing ...
Hirotomo, Nakata +7 more
openaire +2 more sources
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]
, 2017 Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna +3 more
core +2 more sources
Cell Death and Disease, 2021 The pathogenesis of bronchopulmonary dysplasia (BPD), involves inflammatory, mechanisms that are not fully characterized. Here we report that overexpression of C-C chemokine receptor 5 (CCR5) and its ligands is associated with BPD development ...
Ze Chen +5 more
doaj +1 more source
Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
core +1 more source
A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis. [PDF]
ElifeClathrin-mediated endocytosis (CME) is crucial for regulating G protein-coupled receptors (GPCRs) via phosphorylation-dependent arrestin interactions. Despite detailed structural knowledge on the arrestin interactions with phosphorylated tails of GPCRs ...
Petrovic I +5 more
europepmc +2 more sources