Results 21 to 30 of about 104,732 (315)

Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines. [PDF]

Biochemical and Biophysical Research Communications - BBRC, 2000
W. Shen, P. Proost, Baoqun Li, W. Gong, Y. Le, R. Sargeant, P. Murphy, J. Damme, Ji Ming Wang   +8 more
semanticscholar   +2 more sources

Filling the Gaps in Antagonist CCR5 Binding, a Retrospective and Perspective Analysis

Frontiers in Immunology, 2022
The large number of pathologies that position CCR5 as a central molecular determinant substantiates the studies aimed at understanding receptor-ligand interactions, as well as the development of compounds that efficiently block this receptor.
Yerkezhan Amerzhanova, Luca Vangelista
doaj   +1 more source

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
A Kaur, A Llano, A Yates, AN Phillips, Andrea Hegedus, Andrew Worth, B Asquith, Catherine de Lara, D Berhanu, Daniel C. Douek, DC Douek, DC Douek, DC Macallan, DC Macallan, DC Macallan, DC Macallan, DD Ho, Derek Macallan, DL Wallace, EJ Heeregrave, HC Lane, I den Braber, J Embretson, JM Brenchley, JM McCune, JV Giorgi, K Ladell, Karoliina Laamanen, L Cicin-Sain, LJ Picker, M Catalfamo, M Hellerstein, M Koot, MD Hazenberg, MK Hellerstein, MP Davenport, N Brieu, N Vrisekoop, Peter Beverley, R Busch, R Shankarappa, RJ De Boer, RJ De Boer, RM Ribeiro, RM Ribeiro, RS Veazey, SA Handley, TW Chun, V Sanchez, Yan Zhang   +49 more
core   +12 more sources

Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization. [PDF]

PLoS ONE, 2012
Chemokine receptors are members of the G protein-coupled receptor (GPCR) family. CCR5 and CXCR4 act as co-receptors for human immunodeficiency virus (HIV) and several efforts have been made to develop ligands to inhibit HIV infection by blocking those ...
Yi-Qun Kuang, Nicholle Charette, Jennifer Frazer, Patrick J Holland, Kathleen M Attwood, Graham Dellaire, Denis J Dupré   +6 more
doaj   +1 more source

Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]

PLoS Computational Biology, 2018
Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer, Kristyna Pluhackova, Rainer A Böckmann   +2 more
doaj   +1 more source

CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. [PDF]

PLoS Pathogens, 2006
The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired ...
Imtiaz A Khan, Seddon Y Thomas, Magali M Moretto, Frederick S Lee, Sabina A Islam, Crescent Combe, Joseph D Schwartzman, Andrew D Luster   +7 more
doaj   +1 more source

Novel Alleles of the Chemokine-Receptor Gene CCR5 [PDF]

The American Journal of Human Genetics, 1997
The CCR5 gene encodes a cell-surface chemokine-receptor molecule that serves as a coreceptor for macrophage-tropic strains of HIV-1. Mutations in this gene may alter expression or function of the protein product, thereby altering chemokine binding/signaling or HIV-1 infection of cells that normally express CCR5 protein.
Carrington, Mary, Kissner, Teri, Gerrard, Bernard, Ivanov, Sergey, O'Brien, Stephen J., Dean, Michael   +5 more
openaire   +3 more sources

Intragenus variation in a Chemokine Receptor Gene (CCR5) in Homo [PDF]

PLOS ONE, 2017
In comparison to non-human primates, humans have a notable increase in polymorphisms of the regulatory regions of the CCR5 gene, an immune system gene with both general and specific functions. This particular pattern of variation is interpreted as allowing flexibility and diversity of gene expression in response to varying disease loads.
Kara C. Hoover
openalex   +7 more sources

Potent Anti-HIV Chemokine Analogs Direct Post-Endocytic Sorting of CCR5. [PDF]

PLoS ONE, 2015
G protein-coupled receptors (GPCRs) are desensitized and internalized following activation. They are then subjected to post-endocytic sorting (degradation, slow recycling or fast recycling).
Claudia Bönsch, Mihaela Munteanu, Irène Rossitto-Borlat, Alexandre Fürstenberg, Oliver Hartley   +4 more
doaj   +1 more source

Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine–CCR5 interactions [PDF]

Antiviral Therapy, 2009
Background This study aimed to examine how CC chemokine receptor 5 (CCR5) inhibitors (aplaviroc [APL], TAK779 and maraviroc [MVC]) interact with CCR5 and affect its dynamics and physiological CC-chemokine–CCR5 interactions. Methods A yellow fluorescent protein (YFP)-tagged CCR5-expressing U373-MAGI cell line was generated and a stable CCR5-expressing ...
Hirotomo Nakata, Hiromi Ogata-Aoki, Michael J. Kruhlak, Jianfeng Li, Hiroaki Mitsuya, Wakako Kamata, Arun K. Ghosh, Kenji Maeda   +7 more
openaire   +2 more sources