Results 31 to 40 of about 104,732 (315)

Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. [PDF]

Arthritis & Rheumatism, 1999
To investigate whether the pathogenesis of rheumatoid arthritis (RA) is associated with the functional chemokine receptor CCR5, which is the primary CC chemokine receptor expressed by T cells in rheumatoid synovium, and its nonfunctional receptor, delta32CCR5, which is generated by the homozygous 32-basepair deletion (delta32) in the CCR5 gene.The ...
Juan J. G�mez-Reino, J. Pablos, P. Carreira, Bego�a Santiago, L. Serrano, J. Vicario, A. Balsa, M. Figueroa, M. D. de Juan   +8 more
semanticscholar   +4 more sources

Computational study of the structural ensemble of CC chemokine receptor type 5 (CCR5) and its interactions with different ligands.

PLoS ONE, 2022
CC Chemokine receptor 5 (CCR5), a member of the Superfamily of G Protein-Coupled Receptors (GPCRs), is an important effector in multiple physiopathological processes such as inflammatory and infectious entities, including central nervous system ...
Guillermo Goode-Romero, Laura Dominguez
doaj   +1 more source

The Role and Therapeutic Targeting of CCR5 in Breast Cancer

Cells, 2023
The G-protein-coupled receptor C-C chemokine receptor 5 (CCR5) functions as a co-receptor for the entry of HIV into immune cells. CCR5 binds promiscuously to a diverse array of ligands initiating cell signaling that includes guided migration.
Rasha Hamid, Mustafa Alaziz, Amanpreet S. Mahal, Anthony W. Ashton, Niels Halama, Dirk Jaeger, Xuanmao Jiao, Richard G. Pestell   +7 more
doaj   +1 more source

Chemokine Receptor Profiles as Predictors of Survival and Early Progression in Follicular Lymphoma. [PDF]

EJHaem
Abstract Objective: Classical follicular lymphoma (FL) is a heterogeneous malignancy. Early progression within 24 months (POD24) is linked to poor outcomes. However, precise risk stratification remains unclear. We aimed to explore chemokine receptor (CR) expression profiles as potential markers of disease biology and outcome in FL. Methods: We analyzed
Zupo A, Pansy K, Gaksch L, Waldhart J, Brunner A, Strobl J, Szmyra-Polomka M, Haingartner S, Tomazic PV, Greinix HT, Uhl B, Feichtinger J, Stary G, Haybaeck J, Vagena FR, Zacharias M, Beham-Schmid C, Neumeister P, Prochazka KT, Deutsch AJA.   +19 more
europepmc   +2 more sources

Structural basis of dimerization of chemokine receptors CCR5 and CXCR4

Nature Communications, 2023
AbstractG protein-coupled receptors (GPCRs) are prominent drug targets responsible for extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that have been poorly characterized so far. Here, we show the dimerization mechanism of the chemokine receptors CCR5 and CXCR4 by means of an advanced free-energy technique named ...
Di Marino, Daniele, Conflitti, Paolo, Motta, Stefano, Limongelli, Vittorio   +3 more
openaire   +4 more sources

Mechanisms of internalization and recycling of the chemokine receptor, CCR5 [PDF]

European Journal of Biochemistry, 2003
CCR5 is a G protein‐coupled receptor that binds several natural chemokines but it is also a coreceptor for the entry of M tropic strains of HIV‐1 into cells. Levels of CCR5 on the cell surface are important for the rate of HIV‐1 infection and are determined by a number of factors including the rates of CCR5 internalization and recycling.
Mueller, A., Strange, P. G.
openaire   +4 more sources

CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest

Cell Death and Disease, 2021
The pathogenesis of bronchopulmonary dysplasia (BPD), involves inflammatory, mechanisms that are not fully characterized. Here we report that overexpression of C-C chemokine receptor 5 (CCR5) and its ligands is associated with BPD development ...
Ze Chen, Xiaohua Xie, Na Jiang, Jianhui Li, Lei Shen, Yongjun Zhang   +5 more
doaj   +1 more source

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source

Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]

, 2003
To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim, de Lema, Guillermo Pérez, Luckow, Bruno, Mack, Matthias, Schlöndorff, Detlef, Vielhauer, Volker   +5 more
core   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source