Results 41 to 50 of about 48,525 (279)

CCR5 chemokine receptor gene variants in chronic Chagas' disease [PDF]

International Journal of Cardiology, 2014
a Laboratorio de Imunogenetica, Departamento de Biologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 Sao Jose do Rio Preto, SP, Brazil b Departamento de Cardiologia e Cirurgia Cardiovascular, Faculdade de Medicina de Sao Jose do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 Sao ...
Oliveira, Amanda P., Bernardo, Cássia R., Camargo, Ana V.S., Villafanha, Daniel F., Cavasini, Carlos E., Brandão de Mattos, Cinara C., de Godoy, Moacir F., Bestetti, Reinaldo B., de Mattos, Luiz C.   +8 more
openaire   +2 more sources

Intragenus (Homo) variation in a chemokine receptor gene (CCR5)

PLOS ONE, 2018
Humans have a comparatively higher rate of more polymorphisms in regulatory regions of the primate CCR5 gene, an immune system gene with both general and specific functions. This has been interpreted as allowing flexibility and diversity of gene expression in response to varying disease loads.
Kara C. Hoover
openalex   +5 more sources

The Abrogation of Phosphorylation Plays a Relevant Role in the CCR5 Signalosome Formation with Natural Antibodies to CCR5

Viruses, 2017
The exposure to CCR5 (CC chemokine receptor 5) specific natural antibodies in vitro produces a Class B β-arrestin2-dependent CCR5 retention with the aid of ERK1, due to the formation of a CCR5 signalosome, which remains stable for at least 48 h ...
Assunta Venuti, Claudia Pastori, Gabriel Siracusano, Rosamaria Pennisi, Agostino Riva, Massimo Tommasino, Maria Teresa Sciortino, Lucia Lopalco   +7 more
doaj   +1 more source

CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users. [PDF]

PLoS ONE, 2013
Up to 90% HIV-1 positive intravenous drug users (IDUs) are co-infected with HCV. Although best recognized for its function as a major co-receptor for cell entry of HIV, CC chemokine receptor 5 (CCR5) has also been implicated in the pathogenesis of HCV ...
Kristi Huik, Radko Avi, Andrew Carrillo, Nathan Harper, Merit Pauskar, Maarja Sadam, Tõnis Karki, Tõnu Krispin, Ulvi-Kaire Kongo, Tatiana Jermilova, Kristi Rüütel, Ave Talu, Katri Abel-Ollo, Anneli Uusküla, Sunil K Ahuja, Weijing He, Irja Lutsar   +16 more
doaj   +1 more source

Organ-specific features of natural killer cells. [PDF]

, 2011
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio, Ljunggren, Hans-Gustaf, Shi, Fu-Dong, Van Kaer, Luc   +3 more
core   +1 more source

CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis

Acta Tropica, 2018
CC chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Δ32 and CCR5 59029 A/G polymorphisms are associated with the development of ocular toxoplasmosis in humans.
de Faria Junior, Geraldo M., Ayo, Christiane M., de Oliveira, Amanda P., Lopes, Alessandro G., Frederico, Fábio B., Silveira-Carvalho, Aparecida P., Previato, Mariana, Barbosa, Amanda P., Murata, Fernando H.A., de Almeida Junior, Gildásio Castello, Siqueira, Rubens Camargo, de Mattos, Luiz C., Brandão de Mattos, Cinara C.   +12 more
openaire   +4 more sources

Interaction between the CCR5 chemokine receptors and microbial HSP70 [PDF]

European Journal of Immunology, 2006
AbstractEvidence is presented that the microbial 70‐kD heat shock protein (HSP70) binds to CCR5 chemokine receptors in CCR5‐transfected cell lines and in primary human cells. Significant CCR5‐mediated calcium mobilization was stimulated by HSP70 and inhibited with TAK 779, which is a specific CCR5 antagonist.
Whittall, T, Wang, Y F, Younson, J, Kelly, C, Bergmeier, L, Peters, B, Singh, M, Lehner, T   +7 more
openaire   +3 more sources

The case for selection at CCR5-Delta32. [PDF]

PLoS Biology, 2005
The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Delta32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Delta32 arose within the past 1,000 y and rose to its present high frequency
Pardis C Sabeti, Emily Walsh, Steve F Schaffner, Patrick Varilly, Ben Fry, Holli B Hutcheson, Mike Cullen, Tarjei S Mikkelsen, Jessica Roy, Nick Patterson, Richard Cooper, David Reich, David Altshuler, Stephen O'Brien, Eric S Lander   +14 more
doaj   +1 more source

Characterization of the CCR5 chemokine receptor gene [PDF]

Biochemistry and Molecular Biology Education, 2004
AbstractThe life cycle of retroviruses is an essential topic of modern cell biology instruction. Furthermore, the process of HIV viral entry into the cell is a question of great interest in basic and clinical biology. This paper describes how students can easily recover their own DNA, amplify a portion of the CCR5 chemokine receptor gene, characterize ...
openaire   +2 more sources

Envelope-receptor interactions in Nipah virus pathobiology. [PDF]

, 2007
Nipah (NiV) and Hendra (HeV) viruses are members of the newly defined Henipavirus genus of the Paramyxoviridae. Nipah virus (NiV) is an emergent paramyxovirus that causes fatal encephalitis in up to 70% of infected patients, and there is increasing ...
Lee, Benhur
core   +1 more source