Results 41 to 50 of about 104,732 (315)

The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]

, 2017
Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna, J LiWang, Patricia, Jian, Mike, S Schill, Megan   +3 more
core   +2 more sources

A Pocket Guide to CCR5—Neurotropic Flavivirus Edition

Viruses, 2023
CCR5 is among the most studied chemokine receptors due to its profound significance in human health and disease. The notion that CCR5 is a functionally redundant receptor was challenged through the demonstration of its unique protective role in the ...
Amit Garg, Jean K. Lim
doaj   +1 more source

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

CCR3, CCR5, CCR8 and CXCR3 expression in memory T helper cells from allergic rhinitis patients, asymptomatically sensitized and healthy individuals

Clinical and Molecular Allergy, 2006
Background Chemokine receptors have been suggested to be preferentially expressed on CD4+ T cells with CCR3 and CCR8 linked to the T helper (Th) 2 subset and CCR5 and CXCR3 to the Th1 subset, however this remains controversial.
Poulsen Lars K, Assing Kristian, Holse Mille   +2 more
doaj   +1 more source

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim, Sayyed, Sufyan Ali, Vielhauer, Volker   +2 more
core   +1 more source

Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) [PDF]

Journal of Leukocyte Biology, 1999
Abstract The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1á (MIP-1á), MIP-1β, and amino-terminal modifications of RANTES (Met ...
Martin Oppermann, Amanda E. I. Proudfoot, Heike Olbrich   +2 more
openaire   +3 more sources

CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway

Journal of Inflammation, 2009
Background Herpesviruses have evolved chemokines and chemokine receptors, which modulate the recruitment of human leukocytes during the inflammatory response to infection.
Gompels Ursula A, Clark David J, Catusse Julie   +2 more
doaj   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Barton, A., BSPAR Study Group, Childhood Arthritis Prospective Study (CAPS), Eyre, S., Flynn, E., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Hinks, A., Martin, P., Packham, J., Thomson, W., UKRAG Consortium, Worthington, J.   +11 more
core   +2 more sources

Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection

Journal of Experimental Medicine, 2005
The molecular immunopathogenesis of West Nile virus (WNV) infection is poorly understood. Here, we characterize a mouse model for WNV using a subcutaneous route of infection and delineate leukocyte subsets and immunoregulatory factors present in the ...
W. Glass, Jean K. Lim, R. Cholera, A. Pletnev, Ji-Liang Gao, P. Murphy   +5 more
semanticscholar   +1 more source

Characterization of the CCR5 chemokine receptor gene [PDF]

Biochemistry and Molecular Biology Education, 2004
AbstractThe life cycle of retroviruses is an essential topic of modern cell biology instruction. Furthermore, the process of HIV viral entry into the cell is a question of great interest in basic and clinical biology. This paper describes how students can easily recover their own DNA, amplify a portion of the CCR5 chemokine receptor gene, characterize ...
openaire   +3 more sources