Results 51 to 60 of about 104,732 (315)
HEK293T Cells Are Heterozygous for CCR5 Delta 32 Mutation. [PDF]
PLoS ONE, 2016 C-C chemokine receptor 5 (CCR5) is a receptor for chemokines and a co-receptor for HIV-1 entry into the target CD4+ cells. CCR5 delta 32 deletion is a loss-of-function mutation, resistant to HIV-1 infection.
Chunxia Qi +4 more
doaj +1 more source
Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors. [PDF]
, 2017 The homotrimeric HIV-1 envelope glycoprotein (Env) undergoes receptor-triggered structural changes that mediate viral entry through membrane fusion. This process is inhibited by chemokine receptor antagonists (CoRAs) that block Env-receptor interactions ...
Ahn, Koree W., Root, Michael J.
core +2 more sources
Mathematical Model of HIV superinfection dynamics and R5 to X4 switch [PDF]
, 2006 During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively).
Bagnoli, Franco +2 more
core +1 more source
Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection. [PDF]
, 2003 CXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans.
Cannon, C.A., Hosie, M.J., Willett, B.J.
core +2 more sources
Viruses, 2017 The exposure to CCR5 (CC chemokine receptor 5) specific natural antibodies in vitro produces a Class B β-arrestin2-dependent CCR5 retention with the aid of ERK1, due to the formation of a CCR5 signalosome, which remains stable for at least 48 h ...
Assunta Venuti +7 more
doaj +1 more source
CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users. [PDF]
PLoS ONE, 2013 Up to 90% HIV-1 positive intravenous drug users (IDUs) are co-infected with HCV. Although best recognized for its function as a major co-receptor for cell entry of HIV, CC chemokine receptor 5 (CCR5) has also been implicated in the pathogenesis of HCV ...
Kristi Huik +16 more
doaj +1 more source
Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway. [PDF]
, 2012 Pleural tuberculosis (TB), together with lymphatic TB, constitutes more than half of all extrapulmonary cases. Pleural effusions (PEs) in TB are representative of lymphocytic PEs which are dominated by T cells.
Chen, Jianxia +14 more
core +5 more sources
Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice [PDF]
The Journal of Immunology, 2001 AbstractThe chemokine receptors CCR2 and CCR5 play important roles in the recruitment of monocytes/macrophages and T cells. To better understand the role of both receptors in murine models of inflammatory diseases and to recognize potential problems when correlating these data to humans, we have generated mAbs against murine CCR2 and CCR5. In mice CCR2
Christopher Simonis +12 more
openaire +3 more sources
The case for selection at CCR5-Delta32. [PDF]
PLoS Biology, 2005 The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Delta32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Delta32 arose within the past 1,000 y and rose to its present high frequency
Pardis C Sabeti +14 more
doaj +1 more source
Journal of Biological Chemistry, 2001 The CC chemokine receptor CCR5 mediates chemotaxis of leukocytes and serves as a principal co-receptor for macrophage-tropic human immunodeficiency virus type 1.
Katrin Kraft +5 more
semanticscholar +1 more source