Results 71 to 80 of about 48,525 (279)

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Evidence for CD4-enchanced Signaling through the Chemokine Receptor CCR5 [PDF]

Journal of Biological Chemistry, 2003
The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes, but the physiological role of this interaction has not been elucidated. Here we show that detergent-solubilized, purified CCR5 can directly associate with purified soluble fragments of the extracellular portion of CD4.
Robert, Staudinger, Sanjay K, Phogat, Xiaodong, Xiao, Xiahong, Wang, Dimiter S, Dimitrov, Susan, Zolla-Pazner   +5 more
openaire   +2 more sources

The importance of co-receptors in antiretroviral therapy and novel studies on non-peptide, small molecule chemokine receptor type 5 (CCR5) antagonists

İstanbul Journal of Pharmacy
Human immunodeficiency virus (HIV) infection is a major health problem worldwide. Antiretroviral Therapy (ART) involves a combination of HIV drugs (called HIV treatment regimen). However, ART resis5 tance, which emerged because of evolutionary processes,
Dilek Aksoy, Füsun Göktaş Ur
doaj   +1 more source

Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties

Frontiers in Molecular Biosciences, 2022
ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration.
Alessandro Vacchini, Alessandro Vacchini, Elisa Maffioli, Dario Di Silvestre, Cinzia Cancellieri, Samantha Milanesi, Samantha Milanesi, Simona Nonnis, Sabrina Badanai, Pierluigi Mauri, Armando Negri, Massimo Locati, Massimo Locati, Gabriella Tedeschi, Gabriella Tedeschi, Elena Monica Borroni, Elena Monica Borroni   +16 more
doaj   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]

, 2002
Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Cannon, C.A., Hosie, M.J., Willett, B.J.
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Effects of CCL2 chemokine missense mutations on CCR5 receptor affinity: a computational study in the context of HIV infection regulator discovery

Инфекция и иммунитет
Introduction. HIV entry into host cells requires CD4 receptors and CCR5 co-receptors. Natural CCR5 ligands can inhibit HIV through steric blocking and receptor internalization. Although CCL2 is primarily a CCR2 ligand, emerging evidence suggests possible
V. S. Davydenko, Alexandr N. Schemelev, Y. V. Ostankova, E. V. Anufrieva, A. A. Totolian   +4 more
doaj   +1 more source

Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1.

PLoS ONE, 2007
BackgroundStatins have previously been shown to reduce the in vitro infection of human immunodeficiency virus type 1 (HIV-1) through modulation of Rho GTPase activity and lipid raft formation at the cell surface, as well as by disrupting LFA-1 ...
Alexey A Nabatov, Georgios Pollakis, Thomas Linnemann, William A Paxton, Michel P de Baar   +4 more
doaj   +1 more source

Entanglement of CCR5 and Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2019
Although the mechanisms of Alzheimer’s disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable
Tianwen Li, Tianwen Li, Tianwen Li, Jianhong Zhu, Jianhong Zhu, Jianhong Zhu   +5 more
doaj   +1 more source