Results 81 to 90 of about 104,732 (315)

CCR5 chemokine receptor gene variants in chronic Chagas' disease [PDF]

International Journal of Cardiology, 2014
a Laboratorio de Imunogenetica, Departamento de Biologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 Sao Jose do Rio Preto, SP, Brazil b Departamento de Cardiologia e Cirurgia Cardiovascular, Faculdade de Medicina de Sao Jose do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 Sao ...
Cássia Rubia Bernardo, Carlos Eugênio Cavasini, Daniel F. Villafanha, Daniel F. Villafanha, Cinara Cássia Brandão de Mattos, Reinaldo B. Bestetti, Reinaldo B. Bestetti, Amanda Priscila de Oliveira, Ana Vitória da Silveira Camargo, Luiz Carlos de Mattos, Moacir Fernandes de Godoy, Moacir Fernandes de Godoy   +11 more
openaire   +3 more sources

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

Advanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti, Xinyuan Jiang, Xiuying Chen, Mingshu Xiao, Sujing Jiang, Yun Xu, Peng Xiao, Jiangnan Zhao, Kaiyue Zhang, Mengshu Li, Kai Wang   +14 more
wiley   +1 more source

CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis

Acta Tropica, 2018
CC chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Δ32 and CCR5 59029 A/G polymorphisms are associated with the development of ocular toxoplasmosis in humans.
de Faria Junior, Geraldo M., Ayo, Christiane M., de Oliveira, Amanda P., Lopes, Alessandro G., Frederico, Fábio B., Silveira-Carvalho, Aparecida P., Previato, Mariana, Barbosa, Amanda P., Murata, Fernando H.A., de Almeida Junior, Gildásio Castello, Siqueira, Rubens Camargo, de Mattos, Luiz C., Brandão de Mattos, Cinara C.   +12 more
openaire   +5 more sources

Cholesterol impacts chemokine CCR5 receptor ligand‐binding activity [PDF]

The FEBS Journal, 2019
The chemokine CCR5 receptor is target of maraviroc, a negative allosteric modulator of CCR5 that blocks the HIV protein gp120 from associating with the receptor, thereby inhibiting virus cellular entry. As noted with other G‐protein‐coupled receptor family members, the role of the lipid environment in CCR5 signaling remains obscure and very modestly ...
Calmet, Pierre, Cullin, Christophe, Cortès, Sandra, Vang, Maylou, Caudy, Nada, Baccouch, Rim, Dessolin, Jean, Taib Maamar, Nada, Lecomte, Sophie, Tillier, Bruno, Alves, Isabel   +10 more
openaire   +2 more sources

The importance of co-receptors in antiretroviral therapy and novel studies on non-peptide, small molecule chemokine receptor type 5 (CCR5) antagonists

İstanbul Journal of Pharmacy
Human immunodeficiency virus (HIV) infection is a major health problem worldwide. Antiretroviral Therapy (ART) involves a combination of HIV drugs (called HIV treatment regimen). However, ART resis5 tance, which emerged because of evolutionary processes,
Dilek Aksoy, Füsun Göktaş Ur
doaj   +1 more source

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y. L. Lau, Zhiguo Li, Zaal Kokaia, Fu‐Dong Shi, Chao Zhang   +13 more
wiley   +1 more source

Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1.

PLoS ONE, 2007
BackgroundStatins have previously been shown to reduce the in vitro infection of human immunodeficiency virus type 1 (HIV-1) through modulation of Rho GTPase activity and lipid raft formation at the cell surface, as well as by disrupting LFA-1 ...
Alexey A Nabatov, Georgios Pollakis, Thomas Linnemann, William A Paxton, Michel P de Baar   +4 more
doaj   +1 more source

Entanglement of CCR5 and Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2019
Although the mechanisms of Alzheimer’s disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable
Tianwen Li, Tianwen Li, Tianwen Li, Jianhong Zhu, Jianhong Zhu, Jianhong Zhu   +5 more
doaj   +1 more source

Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. [PDF]

PLoS ONE, 2008
BACKGROUND: Dimerization has emerged as an important feature of chemokine G-protein-coupled receptors. CXCR4 and CCR5 regulate leukocyte chemotaxis and also serve as a co-receptor for HIV entry.
Nilgun Isik, Dale Hereld, Tian Jin
doaj   +1 more source