Results 1 to 10 of about 258,547 (150)

Differential Anti-Tumor Effects of IFN-Inducible Chemokines CXCL9, CXCL10, and CXCL11 on a Mouse Squamous Cell Carcinoma Cell Line

Medical Sciences, 2023
Chemokines are a group of cytokines involved in the mobilization of leukocytes, which play a role in host defense and a variety of pathological conditions, including cancer.
Ari Matsumoto, Miki Hiroi, Kazumasa Mori, Nobuharu Yamamoto, Yoshihiro Ohmori   +4 more
doaj   +1 more source

Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities

Viruses, 2023
Background: Multisystem inflammatory syndrome in children (MIS-C), a sequela of severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV2), has been progressively reported worldwide, with cardiac involvement being a frequent presentation ...
Nathella Pavan Kumar, Aishwarya Venkataraman, Arul Nancy, Nandhini Selvaraj, Kadar Moideen, Shaik Fayaz Ahamed, Rachel Marriam Renji, Kandasamy Sasidaran, Sandip Kumar, Muthiah Periyakuppan, Thankgavelu Sangaralingam, Poovazhagi Varadarajan, Elilarasi Chelladurai, Subash Babu   +13 more
doaj   +1 more source

C-C Chemokine Receptor 7 in Cancer [PDF]

Cells, 2022
C-C chemokine receptor 7 (CCR7) was one of the first two chemokine receptors that were found to be upregulated in breast cancers. Chemokine receptors promote chemotaxis of cells and tissue organization. Since under homeostatic conditions, CCR7 promotes migration of immune cells to lymph nodes, questions immediately arose regarding the ability of CCR7 ...
Colin A. Bill, Christopher M. Allen, Charlotte M. Vines   +2 more
openaire   +3 more sources

C-terminal engineering of CXCL12 and CCL5 chemokines: functional characterization by electrophysiological recordings. [PDF]

PLoS ONE, 2014
Chemokines are chemotactic cytokines comprised of 70-100 amino acids. The chemokines CXCL12 and CCL5 are the endogenous ligands of the CXCR4 and CCR5 G protein-coupled receptors that are also HIV co-receptors.
Antoine Picciocchi, Lina Siaučiūnaiteė-Gaubard, Isabelle Petit-Hartlein, Rabia Sadir, Jean Revilloud, Lydia Caro, Michel Vivaudou, Franck Fieschi, Christophe Moreau, Corinne Vivès   +9 more
doaj   +1 more source

Description of an in vivo model for the assessment of eosinophil chemoattractants in the mouse

Memorias do Instituto Oswaldo Cruz, 1997
Chemokines (chemoattractant cytokines) induce potent and selective chemotaxis of leukocyte subsets in vitro. Here, we review briefly the chemokines shown to induce eosinophil chemotaxis in vitro and describe a novel model for the study of the ability of ...
Mauro M Teixeira, Timothy J Williams, Paul G Hellewell   +2 more
doaj   +1 more source

Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients

Immunity, Inflammation and Disease, 2023
Background Chemokines (chemotactic cytokines) are small proteins which are engaged in many pathophysiological processes, including inflammation and homeostasis.
Michal Gniewkiewicz, Jolanta Gozdowska, Dominika Deborska‐Materkowska, Katarzyna Czerwinska, Agnieszka Perkowska‐Ptasinska, Anna Burban, Aleksandra Cieslik, Maciej Kosieradzki, Magdalena Durlik   +8 more
doaj   +1 more source

Chemokines in Physiological and Pathological Bone Remodeling

Frontiers in Immunology, 2019
The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming osteoblasts. These two cell types are fundamentally different in terms of progenitor cells, mode of action and regulation by specific molecules, acting either ...
Laura J. Brylka, Thorsten Schinke
doaj   +1 more source

CXCL3 positively regulates adipogenic differentiation

Journal of Lipid Research, 2016
Chemokines are a family of cytokines inducing cell migration and inflammation. Recent reports have implicated the roles of chemokines in cell differentiation. However, little is known about the functional roles of chemokines in adipocytes.
Joji Kusuyama, Anna Komorizono, Kenjiro Bandow, Tomokazu Ohnishi, Tetsuya Matsuguchi   +4 more
doaj   +1 more source

The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist.

PLoS Pathogens, 2022
Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 different CXC chemokines.
Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau   +9 more
doaj   +1 more source

Chemokine CCL9 Is Upregulated Early in Chronic Kidney Disease and Counteracts Kidney Inflammation and Fibrosis

Biomedicines, 2022
Inflammation and fibrosis play an important pathophysiological role in chronic kidney disease (CKD), with pro-inflammatory mediators and leukocytes promoting organ damage with subsequent fibrosis.
Christian Hemmers, Corinna Schulte, Julia Wollenhaupt, Dickson W. L. Wong, Eva Harlacher, Setareh Orth-Alampour, Barbara Mara Klinkhammer, Stephan H. Schirmer, Michael Böhm, Nikolaus Marx, Thimoteus Speer, Peter Boor, Joachim Jankowski, Heidi Noels   +13 more
doaj   +1 more source