Results 11 to 20 of about 18,097 (179)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer

Frontiers in Molecular Biosciences, 2020
In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya, Naoya Nagaya, Geun Taek Lee, Shigeo Horie, Isaac Yi Kim   +4 more
doaj   +1 more source

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Nature Communications, 2023
CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J. Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M. Deane, Garrett M. Morris, Shoumo Bhattacharya   +13 more
doaj   +1 more source

CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance

International Journal of Inflammation, 2022
Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players.
Kayode Komolafe, Maricica Pacurari
doaj   +1 more source

CC and CXC chemokines play key roles in the development of polyomaviruses related pathological conditions

Virology Journal, 2021
It has been reported that polyomaviruses are the microbes which can be a cause of several human pathological conditions including cancers, nephropathy, progressive multifocal leukoencephalopathy and gynaecological disease. Although investigators proposed
Mohammad Hassan Mohammadi, Ashraf Kariminik   +1 more
doaj   +1 more source

CXC chemokines in angiogenesis

Journal of Leukocyte Biology, 2000
Abstract A variety of factors have been identified that regulate angiogenesis, including the CXC chemokine family. The CXC chemokines are a unique family of cytokines for their ability to behave in a disparate manner in the regulation of angiogenesis.
Belperio, John A., Keane, Michael P., Arenberg, Douglas A., Addison, Christina L., Ehlert, Jan E., Burdick, Marie D., Strieter, Robert M.   +6 more
openaire   +3 more sources

Understanding the immunoangiostatic CXC chemokine network [PDF]

Cardiovascular Research, 2008
Chemokines, originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis. Indeed, they participate in organ development, angiogenesis, tumourigenesis and, more importantly, in the immune response.
BALESTRIERI, Maria Luisa, BALESTRIERI A, MANCINI FP, NAPOLI, Claudio   +3 more
openaire   +3 more sources

Cloning and bioactivity analysis of a CXC ligand in black seabream Acanthopagrus schlegeli: the evolutionary clues of ELR⁺CXC chemokines

BMC Immunology, 2008
Background The ELR+CXC chemokines are multifunctional mediators that are mainly responsible for the recruitment of leucocytes to sites of inflammation and infection.
Kezhi Xing, Yong Zhang, Chunpin Gao, Zhonghua Cai, Yaou Zhang   +4 more
doaj   +1 more source

Targeting Rac1 signaling inhibits streptococcal M1 protein-induced CXC chemokine formation, neutrophil infiltration and lung injury. [PDF]

PLoS ONE, 2013
Infections with Streptococcus pyogenes exhibit a wide spectrum of infections ranging from mild pharyngitis to severe Streptococcal toxic shock syndrome (STSS). The M1 serotype of Streptococcus pyogenes is most commonly associated with STSS.
Songen Zhang, Milladur Rahman, Su Zhang, Lei Song, Heiko Herwald, Henrik Thorlacius   +5 more
doaj   +1 more source

Regulation of Expression of CXC Chemokines in Cultured Hepatocytes [PDF]

Iranian Journal of Public Health, 2005
Chemokines are low molecular weight proteins (8-17 kDa). They are classified in four distinct groups as CXC, CC, CX3C and C. Depending on the presence or absence of a motif called ELR (Arg-Leu-Glu) before the first cysteine residue in their structure ...
GhH Hassanshahiraviz, AJ Dickson
doaj   +2 more sources