The Role of CXC Chemokines in Cardiovascular Diseases [PDF]
Frontiers in Pharmacology, 2022 Cardiovascular disease (CVD) is a class of diseases with high disability and mortality rates. In the elderly population, the incidence of cardiovascular disease is increasing annually.
Jun Wan, Xiyi Lu, Yongqi Feng
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The Role of CXC Chemokines in Cancer Progression. [PDF]
Cancers (Basel), 2022 CXC chemokines are small chemotactic and secreted cytokines. Studies have shown that CXC chemokines are dysregulated in multiple types of cancer and are closely correlated with tumor progression. The CXC chemokine family has a dual function in tumor development, either tumor-promoting or tumor-suppressive depending on the context of cellular signaling.
Wu T, Yang W, Sun A, Wei Z, Lin Q.
europepmc +4 more sources
Prognostic Biomarkers and Immunotherapeutic Targets Among CXC Chemokines in Pancreatic Adenocarcinoma [PDF]
Frontiers in Oncology, 2021 BackgroundPancreatic cancer is one of the principal causes of tumor-related death worldwide. CXC chemokines, a subfamily of functional chemotactic peptides, affect the initiation of tumor cells and clinical outcomes in several human malignant tumors ...
Shengzhang Lin +2 more
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CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance [PDF]
International Journal of Inflammation, 2022 Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players.
Kayode Komolafe, Maricica Pacurari
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Comprehensive analysis of prognostic value and immune infiltration of CXC chemokines in pancreatic cancer [PDF]
BMC Medical Genomics, 2022 Background The prognosis of pancreatic cancer is poor, with a 5-year survival rate of less than 10%. Studies have shown that chemokines in the tumour microenvironment are often altered, which is associated with immune infiltration and the prognosis and ...
Yanhua Jing +3 more
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Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment [PDF]
Cancer Cell International, 2021 Background The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity.
Weina Kong +7 more
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The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors-A Review of Literature. [PDF]
Int J Mol Sci, 2021 Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influence.
Korbecki J +7 more
europepmc +4 more sources
Prognostic Significance and Therapeutic Target of CXC Chemokines in the Microenvironment of Lung Adenocarcinoma [PDF]
International Journal of General Medicine, 2022 Kun Wang, Rongyang Li, Yu Zhang, Weifeng Qi, Tao Fang, Weiming Yue, Hui Tian Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of ChinaCorrespondence: Hui Tian ...
Wang K +6 more
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CXC chemokines in angiogenesis [PDF]
Cytokine and Growth Factor Reviews, 2005 CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis.
Brigitte Gomperts +2 more
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CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment [PDF]
Frontiers in Oncology, 2021 BackgroundSkin Cutaneous Melanoma (SKCM) is a tumor of the epidermal melanocytes induced by gene activation or mutation. It is the result of the interaction between genetic, constitutional, and environmental factors.
Xuezhi Zhou +7 more
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