The Role of CXC Chemokines in Cancer Progression. [PDF]
Cancers (Basel), 2022 CXC chemokines are small chemotactic and secreted cytokines. Studies have shown that CXC chemokines are dysregulated in multiple types of cancer and are closely correlated with tumor progression. The CXC chemokine family has a dual function in tumor development, either tumor-promoting or tumor-suppressive depending on the context of cellular signaling.
Wu T, Yang W, Sun A, Wei Z, Lin Q.
europepmc +4 more sources
Screening of CXC chemokines in the microenvironment of ovarian cancer and the biological function of CXCL10 [PDF]
World Journal of Surgical Oncology, 2021 Background This study aims to screen and identify the biological functions and prognostic value of CXC chemokines in ovarian cancer (OC) through bioinformatics and molecular biology methods, and to provide data support for the selection of biomarkers and
Weiyuan Li +3 more
doaj +2 more sources
A comprehensive bioinformatics analysis to identify potential prognostic biomarkers among CC and CXC chemokines in breast cancer [PDF]
Scientific Reports, 2022 Breast cancer (BC) is a major human health problem due to its increasing incidence and mortality rate. CC and CXC chemokines are associated with tumorigenesis and the progression of many cancers.
Hossein Hozhabri +3 more
doaj +2 more sources
Vaccines, 2022 COVID-19 is one of the progressive viral pandemics that originated from East Asia. COVID-19 or SARS-CoV-2 has been shown to be associated with a chain of physio-pathological mechanisms that are basically immunological in nature.
Pavlos Roditis +2 more
exaly +3 more sources
Regulation of Expression of CXC Chemokines in Cultured Hepatocytes [PDF]
Iranian Journal of Public Health, 2005 Chemokines are low molecular weight proteins (8-17 kDa). They are classified in four distinct groups as CXC, CC, CX3C and C. Depending on the presence or absence of a motif called ELR (Arg-Leu-Glu) before the first cysteine residue in their structure ...
GhH Hassanshahiraviz, AJ Dickson
doaj +3 more sources
High-affinity ELR+ CXC chemokines display balanced G protein-, GRK- and β-arrestin-associated transducer engagement at the viral G protein-coupled receptor ORF74 [PDF]
Frontiers in PharmacologyOpen reading frame 74 (ORF74) is the single G protein-coupled receptor (GPCR) encoded in the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV). Due to its high constitutive activity and broad chemokine binding profile, ORF74 contributes to KSHV ...
Qianqian Kong +4 more
doaj +2 more sources
Molecular Identification and Dual Functions of Two Different CXC Chemokines in Nile Tilapia (Oreochromis niloticus) against Streptococcus agalactiae and Flavobacterium columnare [PDF]
Microorganisms, 2020 Two CXC chemokines in Nile tilapia (On-CXC1 and On-CXC2) were identified at both the genomic and proteomic levels. A southern blot analysis and comparison searching in Ensembl confirmed the typical structure of the CXC chemokine genes and provided ...
Chatsirin Nakharuthai +1 more
doaj +2 more sources
Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. [PDF]
PLoS ONE, 2011 BACKGROUND:Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR(+)) chemokine family are powerful promoters of the angiogenic response.
Anne-Marie Baird +2 more
doaj +3 more sources
Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. [PDF]
PLoS Pathogens, 2010 Chemokines have been found to exert direct, defensin-like antimicrobial activity in vitro, suggesting that, in addition to orchestrating cellular accumulation and activation, chemokines may contribute directly to the innate host response against ...
Matthew A Crawford +7 more
doaj +2 more sources
Identification of Potential Therapeutic Targets Among CXC Chemokines in Breast Tumor Microenvironment Using Integrative Bioinformatics Analysis [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Breast cancer is a common cause of cancer mortality throughout the world. The cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is modulated in part by chemokines ...
Erbao Chen +9 more
doaj +2 more sources