Results 41 to 50 of about 68,560 (212)
BMC Immunology, 2008 Background The ELR+CXC chemokines are multifunctional mediators that are mainly responsible for the recruitment of leucocytes to sites of inflammation and infection.
Kezhi Xing +4 more
doaj +1 more source
Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]
, 2004 Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Anders, Hans-Joachim +3 more
core +1 more source
Understanding the immunoangiostatic CXC chemokine network [PDF]
Cardiovascular Research, 2008 Chemokines, originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis. Indeed, they participate in organ development, angiogenesis, tumourigenesis and, more importantly, in the immune response.
BALESTRIERI, Maria Luisa +3 more
openaire +4 more sources
The role of CXCL family members in different diseases
Cell Death Discovery, 2023 Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability.
Chenjia Zhou +4 more
doaj +1 more source
Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody
mAbs, 2020 CXCR1 and CXCR2 signaling play a critical role in neutrophil migration, angiogenesis, and tumorigenesis and are therefore an attractive signaling axis to target in a variety of indications.
Jeffrey S. Boyles +10 more
doaj +1 more source
Frontiers in Oncology, 2021 The CXC chemokines belong to a family which includes 17 different CXC members. Accumulating evidence suggests that CXC chemokines regulate tumor cell proliferation, invasion, and metastasis in various types of cancers by influencing the tumor ...
Yongchao Li +9 more
doaj +1 more source
CXC Chemokines in Cancer Angiogenesis and Metastases [PDF]
, 2010 The tumor microenvironment is extremely complex that depends on tumor cell interaction with the responding host cells. Angiogenesis, or new blood vessel growth from preexisting vasculature, is a preeminent feature of successful tumor growth of all solid tumors.
Ellen C, Keeley +2 more
openaire +2 more sources
Frontiers in Microbiology, 2019 Parapoxvirus of red deer in New Zealand (PVNZ) is a species of the Parapoxvirus genus that causes pustular dermatitis. We identified a cluster of genes in PVNZ that encode three unique chemokine-binding proteins (CBPs) namely ORF112.0, ORF112.3 and ...
Saeed Sharif +7 more
doaj +1 more source
The role of CXC chemokines in pulmonary fibrosis [PDF]
Journal of Clinical Investigation, 2007 The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes.
Robert M, Strieter +2 more
openaire +2 more sources
BMC Cancer, 2004 Background The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable signal transduction events.
Burdick Marie D +3 more
doaj +1 more source