Results 31 to 40 of about 68,032 (209)

CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer

Frontiers in Molecular Biosciences, 2020
In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya, Naoya Nagaya, Geun Taek Lee, Shigeo Horie, Isaac Yi Kim   +4 more
doaj   +1 more source

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Nature Communications, 2023
CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J. Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M. Deane, Garrett M. Morris, Shoumo Bhattacharya   +13 more
doaj   +1 more source

The Novel Purification and Biophysical Characterization of CXC Chemokines [PDF]

, 2022
The chemokines are small, signaling proteins responsible for leukocyte recruitment through concentration gradient driven responses for inflammatory diseases such as tissue damage or sun burn, tumor suppression and regulation, and obesity from insulin ...
Martin, Patrick
core   +1 more source

Targeting Rac1 signaling inhibits streptococcal M1 protein-induced CXC chemokine formation, neutrophil infiltration and lung injury. [PDF]

PLoS ONE, 2013
Infections with Streptococcus pyogenes exhibit a wide spectrum of infections ranging from mild pharyngitis to severe Streptococcal toxic shock syndrome (STSS). The M1 serotype of Streptococcus pyogenes is most commonly associated with STSS.
Songen Zhang, Milladur Rahman, Su Zhang, Lei Song, Heiko Herwald, Henrik Thorlacius   +5 more
doaj   +1 more source

Cloning and bioactivity analysis of a CXC ligand in black seabream Acanthopagrus schlegeli: the evolutionary clues of ELR⁺CXC chemokines

BMC Immunology, 2008
Background The ELR+CXC chemokines are multifunctional mediators that are mainly responsible for the recruitment of leucocytes to sites of inflammation and infection.
Kezhi Xing, Yong Zhang, Chunpin Gao, Zhonghua Cai, Yaou Zhang   +4 more
doaj   +1 more source

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
Philip John Coates, Torben Wilms, Laurell, Göran,, Rentoft, Matilda,, Coates, Philip John, Matilda Rentoft, Lotta Loljung, Göran Laurell, Karin Nylander, Rentoft, Matilda, Laurell, Göran, Wilms, Torben, Loljung, Lotta, Nylander, Karin, Loljung, Lotta,, Wilms, Torben,, Nylander, Karin,, Coates, Philip John,   +17 more
core   +1 more source

Understanding the immunoangiostatic CXC chemokine network [PDF]

Cardiovascular Research, 2008
Chemokines, originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis. Indeed, they participate in organ development, angiogenesis, tumourigenesis and, more importantly, in the immune response.
BALESTRIERI, Maria Luisa, BALESTRIERI A, MANCINI FP, NAPOLI, Claudio   +3 more
openaire   +4 more sources

The role of CXCL family members in different diseases

Cell Death Discovery, 2023
Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability.
Chenjia Zhou, Ying Gao, Peilun Ding, Tao Wu, Guang Ji   +4 more
doaj   +1 more source

Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody

mAbs, 2020
CXCR1 and CXCR2 signaling play a critical role in neutrophil migration, angiogenesis, and tumorigenesis and are therefore an attractive signaling axis to target in a variety of indications.
Jeffrey S. Boyles, Catherine B. Beidler, Beth A. Strifler, Daniel S. Girard, Zhanna Druzina, Jim D. Durbin, Michelle L. Swearingen, Linda N. Lee, Kristine Kikly, Sudhakar Chintharlapalli, Derrick R. Witcher   +10 more
doaj   +1 more source

Analysis of the Prognosis and Therapeutic Value of the CXC Chemokine Family in Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2021
The CXC chemokines belong to a family which includes 17 different CXC members. Accumulating evidence suggests that CXC chemokines regulate tumor cell proliferation, invasion, and metastasis in various types of cancers by influencing the tumor ...
Yongchao Li, Tinghui Wu, Shujuan Gong, Hangzheng Zhou, Lufei Yu, Meiyan Liang, Ruijun Shi, Zhenhui Wu, Jinpei Zhang, Shuwei Li   +9 more
doaj   +1 more source