The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors-A Review of Literature. [PDF]
Int J Mol Sci, 2021 Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influence.
Korbecki J +7 more
europepmc +4 more sources
Identification of Potential Therapeutic Targets Among CXC Chemokines in Breast Tumor Microenvironment Using Integrative Bioinformatics Analysis [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Breast cancer is a common cause of cancer mortality throughout the world. The cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is modulated in part by chemokines ...
Erbao Chen +9 more
doaj +3 more sources
Catecholamines Promote Ovarian Cancer Progression through Secretion of CXC-Chemokines. [PDF]
Int J Mol Sci, 2023 Considerable evidence has accumulated in the last decade supporting the notion that chronic stress is closely related to the growth, metastasis, and angiogenesis of ovarian cancer.
Kim HJ, Chang HK, Lee YM, Heo K.
europepmc +2 more sources
Prognostic Significance and Immune Cell Infiltration Analysis of CXC Chemokines in Glioblastoma
Zhongliu Fangzhi Yanjiu, 2021 Objective To analyze the expression of CXC chemokines in glioblastoma (GBM), and investigate their prognostic value and potential roles as therapeutic targets. Methods Differential expression and prognostic value of CXC chemokines in GBM were obtained in
LIU Fangyuan, SU Xiulan
doaj +1 more source
The CC and CXC chemokines: major regulators of tumor progression and the tumor microenvironment
American Journal of Physiology - Cell Physiology, 2020 Andrea Bikfalvi
exaly +2 more sources
Frontiers in Cell and Developmental Biology, 2023 Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births.
Amin Ullah +4 more
doaj +1 more source
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
Image_8_Prognostic Biomarkers and Immunotherapeutic Targets Among CXC Chemokines in Pancreatic Adenocarcinoma.tif [PDF]
, 2021 BackgroundPancreatic cancer is one of the principal causes of tumor-related death worldwide. CXC chemokines, a subfamily of functional chemotactic peptides, affect the initiation of tumor cells and clinical outcomes in several human malignant tumors ...
Jiacheng Huang (1639390) +5 more
core +1 more source
Production of CXC and CC chemokines by human antigen-presenting cells in response to Lassa virus or closely related immunogenic viruses, and in cynomolgus monkeys with lassa fever. [PDF]
PLoS Neglected Tropical Diseases, 2014 The pathogenesis of Lassa fever (LF), a hemorrhagic fever endemic to West Africa, remains unclear. We previously compared Lassa virus (LASV) with its genetically close, but nonpathogenic homolog Mopeia virus (MOPV) and demonstrated that the strong ...
Delphine Pannetier +4 more
doaj +1 more source
Image_1_Prognostic Biomarkers and Immunotherapeutic Targets Among CXC Chemokines in Pancreatic Adenocarcinoma.tif [PDF]
, 2021 BackgroundPancreatic cancer is one of the principal causes of tumor-related death worldwide. CXC chemokines, a subfamily of functional chemotactic peptides, affect the initiation of tumor cells and clinical outcomes in several human malignant tumors ...
Jiacheng Huang (1639390) +5 more
core +1 more source