The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature [PDF]
International Journal of Molecular Sciences, 2021 Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influence.
Jan Korbecki +2 more
exaly +6 more sources
CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer [PDF]
Frontiers in Molecular Biosciences, 2020 In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya +2 more
exaly +4 more sources
CXC chemokine receptor type 5 may induce trophoblast dysfunction and participate in the processes of unexplained missed abortion, wherein p-ERK and interleukin-6 may be involved [PDF]
HeliyonChemokines regulate the trophoblast dysfunction involved in the occurrence and development of pathological pregnancy, including missed abortions. In particular, CXC chemokine receptor type 5 mediates cell proliferation, migration, and inflammation ...
Yanan Zhi +6 more
doaj +3 more sources
PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR+ CXC chemokine expression [PDF]
EMBO Molecular Medicine, 2022 The pathological retinal angiogenesis often causes blindness. Current anti‐angiogenic therapy for proliferative retinopathy targets the vascular endothelial growth factor (VEGF), but many patients do not radically benefit from this therapy.
Yan Zhao +18 more
doaj +3 more sources
Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody [PDF]
mAbs, 2020 CXCR1 and CXCR2 signaling play a critical role in neutrophil migration, angiogenesis, and tumorigenesis and are therefore an attractive signaling axis to target in a variety of indications.
Jeffrey S. Boyles +10 more
doaj +3 more sources
CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response [PDF]
Advanced ScienceAberrant tumor vasculature drives hypoxia, immune exclusion, and therapeutic resistance. However, current vascular normalization strategies remain primarily VEGF‐centered, relying on morphological and perfusion metrics with limited molecular readouts to ...
Hongdan Chen +7 more
doaj +2 more sources
Biophysical characterization of the CXC chemokine receptor 2 ligands. [PDF]
PLoS ONEThe chemokines of the immune system act as first responders by operating as chemoattractants, directing immune cells to specific locations of inflamed tissues.
Patrick Martin +9 more
doaj +2 more sources
CXC chemokines in angiogenesis [PDF]
Cytokine & Growth Factor Reviews, 2005 CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis.
Robert M, Strieter +4 more
openaire +3 more sources
Frontiers in Pharmacology, 2023 Dengzhan Shengmai (DZSM), a traditional Chinese medicine formulation, has been administered extensively to elderly individuals with cognitive impairment (CI).
Jing-Yi Hou +12 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundPancreatic cancer is one of the principal causes of tumor-related death worldwide. CXC chemokines, a subfamily of functional chemotactic peptides, affect the initiation of tumor cells and clinical outcomes in several human malignant tumors ...
Jiacheng Huang +9 more
doaj +1 more source