Results 41 to 50 of about 88,618 (194)

Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis

BMC Cancer, 2004
Background The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable signal transduction events.
Burdick Marie D, Belperio John A, Addison Christina L, Strieter Robert M   +3 more
doaj   +1 more source

CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]

, 2010
CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is
Pruenster, M, Mahabaleshwar, Harsha, Ulrike Naumann, Raz Erez, Rot, Antal, Rot Antal, Marcus Thelen, Naumann, U, Zerwes Hans-Günter, Harsha Mahabaleshwar, Naumann Ulrike, Cameroni, E, Mahabaleshwar, H, Elisabetta Cameroni, Zerwes, Hans-Günter, Raz, E, Pruenster Monika, Mahabaleshwar Harsha, Monika Pruenster, Hans-Günter Zerwes, Pruenster, Monika, Thelen, M, Thelen Marcus, Naumann, Ulrike, Cameroni, Elisabetta, Cameroni Elisabetta, Raz, Erez, Zerwes, HG, Antal Rot, Erez Raz, Thelen, Marcus, Raz E, Cameroni E, Mahabaleshwar H, Zerwes HG, Naumann U, Rot A, Pruenster M, Thelen M   +38 more
core   +1 more source

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Nature Communications, 2018
CXCR2 antagonism has been shown to be anti-arthritic, but anti-chemokine therapies usually fail in the clinic owing to redundancy in chemokine-receptor interactions.
Alessandro Angelini, Yoshishige Miyabe, Daniel Newsted, Byron H. Kwan, Chie Miyabe, Ryan L. Kelly, Misha N. Jamy, Andrew D. Luster, K. Dane Wittrup   +8 more
doaj   +1 more source

Proposed mechanism of TXA2-induced CXC chemokine expression in NMDFs.

, 2016
Proposed mechanism of TXA2-induced CXC chemokine expression in NMDFs.
Sheng-Po Hao (738299), Wen-Bin Wu (738302), Chih-Li Chen (738300), Yih-Jeng Tsai (738298)   +3 more
core   +1 more source

Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. [PDF]

PLoS Pathogens, 2010
Chemokines have been found to exert direct, defensin-like antimicrobial activity in vitro, suggesting that, in addition to orchestrating cellular accumulation and activation, chemokines may contribute directly to the innate host response against ...
Matthew A Crawford, Marie D Burdick, Ian J Glomski, Anne E Boyer, John R Barr, Borna Mehrad, Robert M Strieter, Molly A Hughes   +7 more
doaj   +1 more source

Chemokines and immunity

Einstein (São Paulo)
Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells.
Diana Carolina Torres Palomino, Luciana Cavalheiro Marti   +1 more
doaj   +1 more source

Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells

Nature Communications, 2023
Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors.
Taichi Nakatani, Tatsuki Sugiyama, Yoshiki Omatsu, Hitomi Watanabe, Gen Kondoh, Takashi Nagasawa   +5 more
doaj   +1 more source

Transcriptomic Analysis of the Effects of Chemokine Receptor CXCR3 Deficiency on Immune Responses in the Mouse Brain during Toxoplasma gondii Infection

Microorganisms, 2021
The obligate intracellular parasite Toxoplasma gondii infects warm-blooded animals, including humans. We previously revealed through a whole-brain transcriptome analysis that infection with T.
Kousuke Umeda, Youta Goto, Kenichi Watanabe, Nanako Ushio, Ragab M. Fereig, Fumiaki Ihara, Sachi Tanaka, Yutaka Suzuki, Yoshifumi Nishikawa   +8 more
doaj   +1 more source

The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3 [PDF]

Proceedings of the National Academy of Sciences, 1998
We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine.
H, Soto, W, Wang, R M, Strieter, N G, Copeland, D J, Gilbert, N A, Jenkins, J, Hedrick, A, Zlotnik   +7 more
openaire   +2 more sources

ELR CXC chemokine expression in benign and malignant colorectal conditions-8

, 2011
< 0.05, ** < 0.001, = 30 and 48, respectively. Fold increase above 1 indicates chemokine overexpression in CRA and CRC tissues related to unaffected neighbor tissues, respectively.Copyright information:Taken from "ELR+ CXC chemokine expression in benign ...
Claudia Rubie (55165), Mathias Wagner (55167), Brigitte Brittner (55170), Stefan Gräber (55169), Vilma Oliveira Frick (55166), Jochen Schuld (55168), Rainer M Bohle (5493), Martin K Schilling (55171)   +7 more
core   +1 more source