Results 21 to 30 of about 88,618 (194)

CXC chemokines in angiogenesis

Journal of Leukocyte Biology, 2000
Abstract A variety of factors have been identified that regulate angiogenesis, including the CXC chemokine family. The CXC chemokines are a unique family of cytokines for their ability to behave in a disparate manner in the regulation of angiogenesis.
Belperio, John A., Keane, Michael P., Arenberg, Douglas A., Addison, Christina L., Ehlert, Jan E., Burdick, Marie D., Strieter, Robert M.   +6 more
openaire   +3 more sources

CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment

Frontiers in Oncology, 2021
BackgroundSkin Cutaneous Melanoma (SKCM) is a tumor of the epidermal melanocytes induced by gene activation or mutation. It is the result of the interaction between genetic, constitutional, and environmental factors.
Xuezhi Zhou, Manjuan Peng, Ye He, Jingjie Peng, Xuan Zhang, Chao Wang, Xiaobo Xia, Weitao Song   +7 more
doaj   +1 more source

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
Philip John Coates, Torben Wilms, Laurell, Göran,, Rentoft, Matilda,, Coates, Philip John, Matilda Rentoft, Lotta Loljung, Göran Laurell, Karin Nylander, Rentoft, Matilda, Laurell, Göran, Wilms, Torben, Loljung, Lotta, Nylander, Karin, Loljung, Lotta,, Wilms, Torben,, Nylander, Karin,, Coates, Philip John,   +17 more
core   +1 more source

A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. [PDF]

J Biol Chem, 2019
\ua9 2019 American Society for Biochemistry and Molecular Biology Inc. All rights reserved.Tick evasins (EVAs) bind either CC- or CXC-chemokines by a poorly understood promiscuous or "one-to-many" mechanism to neutralize inflammation.
Lee AW, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, Eaton JRO, Kawamura A, Shaw J, Proudfoot AEI, Dias JM, Bhattacharya S.   +11 more
europepmc   +2 more sources

The Role of CXC Chemokines in Cardiovascular Diseases

Frontiers in Pharmacology, 2022
Cardiovascular disease (CVD) is a class of diseases with high disability and mortality rates. In the elderly population, the incidence of cardiovascular disease is increasing annually. Between 1990 and 2016, the age-standardised prevalence of CVD in China significantly increased by 14.7%, and the number of cardiovascular disease deaths increased from 2.
Xiyi Lu, Zhen Wang, Di Ye, Yongqi Feng, Menglin Liu, Yao Xu, Menglong Wang, Jishou Zhang, Jianfang Liu, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wan   +12 more
openaire   +3 more sources

The Role of CXCL12 in Kidney Diseases: A Friend or Foe?

Kidney Diseases, 2021
Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song, Anni Jiang, Wei Xiong, Chun Zhang   +3 more
doaj   +1 more source

The Role of CXC Chemokines in Cancer Progression

Cancers, 2022
CXC chemokines are small chemotactic and secreted cytokines. Studies have shown that CXC chemokines are dysregulated in multiple types of cancer and are closely correlated with tumor progression. The CXC chemokine family has a dual function in tumor development, either tumor-promoting or tumor-suppressive depending on the context of cellular signaling.
Tiantian Wu, Wannian Yang, Aiqin Sun, Zhixiao Wei, Qiong Lin   +4 more
openaire   +2 more sources

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets [PDF]

, 2018
Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast
Philip Elders, Yara Alenazi, James R. O. Eaton, Shoumo Bhattacharya, Akane Kawamura, Kamayani Singh, Graham Davies   +6 more
core   +3 more sources

CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats.

PLoS ONE, 2014
Successful curative treatment of severe pulmonary arterial hypertension with luminal obliteration will require a thorough understanding of the mechanism underlying the development and progression of pulmonary vascular lesions.
Daniela Farkas, Donatas Kraskauskas, Jennifer I Drake, Aysar A Alhussaini, Vita Kraskauskiene, Harm J Bogaard, Carlyne D Cool, Norbert F Voelkel, Laszlo Farkas   +8 more
doaj   +1 more source

CXCL11 mediates TWIST1-induced angiogenesis in epithelial ovarian cancer

Tumor Biology, 2017
To investigate the role of TWIST1 in tumor angiogenesis in epithelial ovarian cancer and to identify key molecules involved in angiogenesis. TWIST1 small interfering RNA was transfected into A2780 cells, while a complementary DNA vector was transfected ...
Yu-Jin Koo, Tae-Jin Kim, Kyung-Jin Min, Kyeong-A So, Un-Suk Jung, Jin-Hwa Hong   +5 more
doaj   +1 more source