Targeting Rac1 signaling inhibits streptococcal M1 protein-induced CXC chemokine formation, neutrophil infiltration and lung injury. [PDF]
PLoS ONE, 2013 Infections with Streptococcus pyogenes exhibit a wide spectrum of infections ranging from mild pharyngitis to severe Streptococcal toxic shock syndrome (STSS). The M1 serotype of Streptococcus pyogenes is most commonly associated with STSS.
Songen Zhang +5 more
doaj +3 more sources
Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity. [PDF]
PLoS Biology, 2020 Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets.
Tony Ngo +6 more
doaj +2 more sources
Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling [PDF]
Nature Communications, 2023 CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales +13 more
doaj +2 more sources
Exploring Chemokine Homodimer Stability: Structural Insights into CXC and CC Interfaces
BiophysicaChemokine ligands play a pivotal role in immune response by mediating cell migration and coordinating cellular processes through interactions with chemokine receptors. Understanding their sequence and structural integrity is crucial for elucidating their
David Budean +5 more
doaj +2 more sources
CXC chemokines in angiogenesis [PDF]
Cytokine & Growth Factor Reviews, 2005 CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis.
Robert M, Strieter +4 more
openaire +3 more sources
ELR+ CXC chemokine signalling in cartilage homeostasis. [PDF]
, 2011 PhDThe production of ELR+ CXC chemokines is widely studied in arthritis and has been postulated to contribute to the inflammatory phenomena that eventually lead to cartilage breakdown.
Sherwood, Joanna
core +4 more sources
BMC Medical Genomics, 2022 Background The prognosis of pancreatic cancer is poor, with a 5-year survival rate of less than 10%. Studies have shown that chemokines in the tumour microenvironment are often altered, which is associated with immune infiltration and the prognosis and ...
Yanhua Jing +3 more
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Production of CXC and CC chemokines by human antigen-presenting cells in response to Lassa virus or closely related immunogenic viruses, and in cynomolgus monkeys with lassa fever. [PDF]
PLoS Neglected Tropical Diseases, 2014 The pathogenesis of Lassa fever (LF), a hemorrhagic fever endemic to West Africa, remains unclear. We previously compared Lassa virus (LASV) with its genetically close, but nonpathogenic homolog Mopeia virus (MOPV) and demonstrated that the strong ...
Delphine Pannetier +4 more
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Recent Advances in CXCL12/CXCR4 Antagonists and Nano-Based Drug Delivery Systems for Cancer Therapy
Pharmaceutics, 2022 Chemokines can induce chemotactic cell migration by interacting with G protein-coupled receptors to play a significant regulatory role in the development of cancer.
Ruogang Zhao +5 more
doaj +1 more source
Microorganisms, 2020 Two CXC chemokines in Nile tilapia (On-CXC1 and On-CXC2) were identified at both the genomic and proteomic levels. A southern blot analysis and comparison searching in Ensembl confirmed the typical structure of the CXC chemokine genes and provided ...
Chatsirin Nakharuthai +1 more
doaj +1 more source