Results 51 to 60 of about 68,560 (212)
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets [PDF]
, 2018 Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast
Philip Elders +6 more
core +3 more sources
Evasins: Biology and Therapeutic Potential of Broad-Spectrum Chemokine Inhibitors. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Bialek EL +3 more
europepmc +2 more sources
TRIM proteins and CXS chemokines : evolutionary dynamics and functional characterization of two large protein families in teleost fish [PDF]
, 2012 Two large protein families with roles in the immune system were the subject of this thesis. In part one of the thesis, TRIM proteins were studied, which are part of an ancient intracellular immune system. In mammals, TRIM proteins were recently found to
Aa, L.M., van der
core
The Novel Purification and Biophysical Characterization of CXC Chemokines [PDF]
, 2022 The chemokines are small, signaling proteins responsible for leukocyte recruitment through concentration gradient driven responses for inflammatory diseases such as tissue damage or sun burn, tumor suppression and regulation, and obesity from insulin ...
Martin, Patrick
core
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source
Einstein (São Paulo)Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells.
Diana Carolina Torres Palomino +1 more
doaj +1 more source
Biology, 2022 A mild to moderate increase in acute-phase proteins (APPs) and a decrease in serum albumin levels are detected in hospitalized COVID-19 patients. A similar trend is also observed for acute-phase cytokines (APC), mainly IL6, besides chemokines (e.g ...
Ihtzaz Ahmed Malik, Giuliano Ramadori
doaj +1 more source
The expression and role of CXC chemokines in colorectal cancer
, 2011 <p>Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially
G. Laureys +12 more
core +1 more source
Novel CXCR2â dependent liver regenerative qualities of ELRâ containing CXC chemokines [PDF]
, 1999 Severe acute liver injury due to accidental or intentional acetaminophen overdose presents a major clinical dilemma often requiring liver transplantation.
Lukacs, Nicholas W. +15 more
core +1 more source
Advanced Science, EarlyView.An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan +7 more
wiley +1 more source