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Chemoprevention has been shown to be an extremely promising approach to the prevention of invasive cancer. Through the identification of chemopreventive agents that inhibit or reverse the process of carcinogenesis, new strategies of early intervention can be developed for patients at high risk that potentially prevent the onset of invasive and ...
Peter Greenwald +2 more
exaly +3 more sources
Chemoprevention of Cancer [PDF]
Cancer chemoprevention is defined as the use of natural, synthetic, or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression to invasive cancer. The success of several recent clinical trials in preventing cancer in high-risk populations suggests that chemoprevention is a rational and appealing strategy.
Anne S Tsao, Waun Ki Hong, Edward S Kim
exaly +3 more sources
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Current Problems in Cancer, 1994
Chemoprevention is a strategy used to block the development of cancers in human beings. This emerging field has broad potential for influencing cancer incidence rates in defined high-risk groups and the general population. In this review, we define some of the mechanisms of carcinogenesis, describe some of the genetic markers of carcinogenesis, and ...
C E, Szarka, G, Grana, P F, Engstrom
openaire +2 more sources
Chemoprevention is a strategy used to block the development of cancers in human beings. This emerging field has broad potential for influencing cancer incidence rates in defined high-risk groups and the general population. In this review, we define some of the mechanisms of carcinogenesis, describe some of the genetic markers of carcinogenesis, and ...
C E, Szarka, G, Grana, P F, Engstrom
openaire +2 more sources
Chemoprevention by Pyrimethamine
Immunopharmacology and Immunotoxicology, 2005The goal of the current research was to investigate the chemopreventive potency of an antimalaria drug, pyrimethamine, in in vitro conditions. The fibrosarcoma (WEHI-164) cell line was used for evaluating cytotoxicity, matrix metalloproteinase 2 (MMP-2) activity, and apoptosis. Pyrimethamine and methotrexate were used at concentrations of 0-8 microg/ml
Farshid, Saadat +2 more
openaire +2 more sources
Journal of the American Academy of Dermatology, 2006
Despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures.We sought to summarize the results of published research on candidate chemoprevention agents for ...
Shayla O, Francis +4 more
openaire +2 more sources
Despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures.We sought to summarize the results of published research on candidate chemoprevention agents for ...
Shayla O, Francis +4 more
openaire +2 more sources
Hematology/Oncology Clinics of North America, 1991
Chemoprevention is a relatively new area of clinical cancer research. In this article we have presented a general overview of the concepts as well as the status of ongoing clinical trials using the most promising agents in selected populations. The reader is referred to recent excellent reviews presenting more detailed discussions of the various topics
H S, Garewal, F L, Meyskens
openaire +2 more sources
Chemoprevention is a relatively new area of clinical cancer research. In this article we have presented a general overview of the concepts as well as the status of ongoing clinical trials using the most promising agents in selected populations. The reader is referred to recent excellent reviews presenting more detailed discussions of the various topics
H S, Garewal, F L, Meyskens
openaire +2 more sources

