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Chemoprevention of Cancer

Scientific American, 1996
Chemoprevention of cancer is a means of cancer control in which the occurrence of this disease is prevented by administra tion of one or several chemical compounds. This Perspective deals with the areas in cancer control that this field addresses, the promise that it holds, and the problems that must be solved in order to realize its goals.
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Chemoprevention by isothiocyanates

Journal of Cellular Biochemistry, 1995
Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase ...
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Cancer chemoprevention

Current Opinion in Gastroenterology, 1999
Chemoprevention is defined as nutritional or pharmaceutical interventions designed to prevent or delay cellular transformation. Over the last year, the great excitement and interest in the mechanism, epidemiology, and preclinical and clinical chemopreventive effects in the lower intestine of nonsteroidal anti-inflammatory drugs continues and is ...
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Cancer chemoprevention

Cancer, 1993
Encouraging results from several recent trials have increased interest in the potential of chemoprevention in reducing the incidence of cancer. Treatment with 13-cis-retinoic acid has reversed oral leukoplakia, a premalignant lesion, and prevented the development of second primary carcinomas of the head and neck.
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Chemoprevention of Cancer

Acta Oncologica, 1998
Although there is strong epidemiological evidence to suggest the preventability of many cancers based on non-experimental studies at both ecological and individual levels, there have been few applications of that knowledge to randomized trials. The randomized trials were mainly designed to demonstrate the effect of chemoprevention on risk of cancer ...
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Resveratrol and chemoprevention

Cancer Letters, 2009
Resveratrol is a phytoalexin, highly abundant in skins of red grapes and moderately abundant in peanuts and blueberries. Originally a constituent of oriental medicines, it has lately been rediscovered for a plethora of beneficial properties such as anti-cancer, anti-aging, antiviral, cardiovascular and neuroprotective effects, thereby making it one of ...
Shyamal K, Goswami, Dipak K, Das
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Screening and chemoprevention

Critical Reviews in Oncology/Hematology, 1998
Detection of cancer at an early stage, by screening asymptomatic persons who are at risk for cancer has the aim of decreasing the number of cancer-related deaths. In practice, there are no guidelines for cancer screening in older people and it is often neglected, since reduced life expectancy and competing causes of death are considered to reduce the ...
L, Repetto   +3 more
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Chemoprevention of melanoma

Current Oncology Reports, 2004
The United States is experiencing a surge in the incidence of cutaneous malignant melanoma. Because melanoma is typically refractory to available anticancer therapy, exploration of preventive strategies has become a priority. In this review, the rationale for chemoprevention, a new and potentially powerful approach to controlling melanoma, is discussed.
Marie-France, Demierre, Glenn, Merlino
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Chemoprevention of breast cancer

Breast Cancer Research and Treatment, 1989
The hypothesis that oestrogen is an important promoter of human breast cancer raises the possibility that endocrine intervention could prevent the disease. Various methods of reducing oestrogenic activity have been proposed including dietary control, progestin therapy, and ovarian ablation.
Powles, TJ   +11 more
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Chemoprevention of Lung Cancer

Current Opinion in Pulmonary Medicine, 2004
Lung cancer is one of the major causes of cancer-related deaths. Grim mortality figures argue powerfully for new approaches to control this disease. Chemoprevention is the use of specific natural or synthetic chemical agents to reverse, suppress, or prevent carcinogenic progression to invasive cancer.
Victor, Cohen, Fadlo R, Khuri
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