Results 81 to 90 of about 33,930 (226)

Rationalizing Proton Pump Inhibitor Use: Southeast Asia Consensus Recommendations

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1685-1700, June 2026.
ABSTRACT Background and Aim Proton pump inhibitors (PPIs) are integral to managing many gastrointestinal conditions. However, the prevalent inappropriate PPI prescription across Southeast Asia (SEA) is concerning. Given the absence of locally tailored recommendations to inform clinical practice, this consensus document aims to provide recommendations ...
Somchai Leelakusolvong, Tju Siang Chua, Duc Trong Quach, Andrew Ming‐Liang Ong, Ari Fahrial Syam, Augusto Jose G. Galang, Wee Kooi Cheah, Hang Viet Dao, Jose D. Sollano, Kalwinder Singh Khaira, Phuripong Kijdamrongthum, Rahela Ambaras Khan, Sakkarin Chirapongsathorn, Yeong Yeh Lee   +13 more
wiley   +1 more source

Caesalpinia sappan L. Ethanolic Extract Decrease Intracellular ROS Level and Senescence of 4T1 Breast Cancer Cells

, 2019
Highly and uncontrolled cell proliferation on cancer cells may boost ROS level intracellular accumulation up significantly. Sappan heartwood (Caesalpinia sappan L.) have been known to have cytotoxicity effect toward several cancer cells.
Hermawan, Adam, Hanif, Naufa, Meiyanto, Edy   +2 more
core   +1 more source

The Combination of Sorafenib and PGV-1 Inhibits the Proliferation of Hepatocellular Carcinoma Through c-Myc Suppression in an Additive Manner: In Vitro Studies

Advances in Pharmacological and Pharmaceutical Sciences
Hepatocellular carcinoma (HCC) is one of the most aggressive types of liver cancer, and it is frequently associated with upregulated c-Myc expression.
Dhania Novitasari, Ikuko Nakamae, Noriko Yoneda-Kato, Jun-ya Kato, Yoshitaka Hippo, Yusuke Suenaga, Dyaningtyas Dewi Pamungkas Putri, Edy Meiyanto, Muthi’ Ikawati   +8 more
doaj   +1 more source

Preparation and Performance of Phthalocyanine @ Copper Iodide Cluster Nanoparticles for X-Ray-Induced Photodynamic Therapy

Molecules
The efficacy of X-ray-induced photodynamic therapy (X-PDT) for deep tumors is often hindered by conventional scintillators, typically rare-earth nanoparticles plagued by long-term toxicity and suboptimal scintillation yields.
Wei Xie, Yunan Li, Guoyan Tang, Zhihua Li, Mengyu Yao, Biyuan Zheng, Xingshu Li, Jian-Dong Huang   +7 more
doaj   +1 more source

Clinical Outcomes of Selenium Supplementation in Hashimoto's Thyroiditis Without Selenium Deficiency: A Large‐Scale Retrospective Cohort Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Selenium supplementation among patients with Hashimoto's thyroiditis does not benefit thyroid biomarkers and can worsen autoimmune comorbidities, especially when they are not selenium‐deficient to begin with. ABSTRACT Introduction Selenium supplementation has been suggested as a therapeutic option for Hashimoto's thyroiditis, but its effects on thyroid
Eman A. Toraih, Sarah Yaghi, Claire Ardis, Lori Tran, Ahmed Abdelmaksoud, Rami M. Elshazli, Mohammad H. Hussein, Hinali Patel, Ekramy M. Elmorsy, Jessan A. Jishu, Hani Aiash, Manal S. Fawzy   +11 more
wiley   +1 more source

Epidemiology, Risk Factors and Pathophysiology of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: An Update

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique clinical syndrome affecting up to 80% of PSC patients, characterised by distinct epidemiological patterns, pathophysiological mechanisms and clinical outcomes that differ substantially from either condition occurring independently ...
Luisa Bertin, Paul Henderson, Richard Pollok, Natália Queiroz, Luca Fabris, Edoardo Vincenzo Savarino, Iago Rodríguez‐Lago, Brigida Barberio   +7 more
wiley   +1 more source

Chemoprevention of Colorectal Cancer

, 1996
This review summarizes the principles of cancer chemoprevention and discusses the evidence from epidemiologic and experimental studies and preclinical and clinical trials of potential colorectal chemopreventive agents.
Brenner, D E., Krishnan, K
core   +1 more source

Discovery of pyroptosis-inducing natural products in neuroblastomas: computational studies with experimental validation

BMC Complementary Medicine and Therapies
Background Neuroblastomas evade apoptosis due to oncogene mutations and antiapoptotic proteins, necessitating novel therapeutics that work in concert with other forms of cell death.
Beni Lestari, Rohmad Yudi Utomo, Faaza Aulia Rahman, Dyaningtyas Dewi Pamungkas Putri, Ummi Maryam Zulfin, Yusuke Suenaga, Edy Meiyanto, Yoshitaka Hippo   +7 more
doaj   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source