Results 51 to 60 of about 87,208 (292)

Intratumoral Fusobacterium nucleatum Drives Cancer‐Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Fusobacterium nucleatum contributes to the progression of ESCC by inducing NF‐κB–mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, F.
Takashi Ofuchi, Qingjiang Hu, Kazuki Omachi, Kosuke Kanemitsu, Hajime Otsu, Yusuke Yonemura, Taro Tobo, Yoshifumi Baba, Masaaki Iwatsuki, Koshi Mimori   +9 more
wiley   +1 more source

Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database

Frontiers in Immunology
BackgroundWhile simultaneous chemoradiotherapy remains the established therapeutic modality for patients afflicted with locally advanced esophageal cancer, the effectiveness of this radical approach falls short of the desired outcome.
Liangyun Xie, Liangyun Xie, Zhi Zhang
doaj   +1 more source

Total Neoadjuvant Therapy for Rectal Cancer: Why Japan Says “Not Yet”

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Total neoadjuvant therapy (TNT) has rapidly gained global acceptance as a standard treatment for locally advanced rectal cancer (LARC). Supported by multiple phase III trials, TNT improves pathological complete response (pCR) rates, enhances systemic control, and expands opportunities for non‐operative management (NOM).
Kay Uehara, Akihisa Matsuda, Takeshi Yamada, Aitsariya Monkhonsupphawan, Hiroshi Yoshida   +4 more
wiley   +1 more source

Asthma caused by durvalumab after chemoradiotherapy in two patients with non‐small cell lung cancer

Respirology Case Reports, 2021
Durvalumab, an anti‐programmed cell death‐ligand 1 (PD‐L1) antibody, is currently used in the maintenance therapy for patients with stage III non‐small cell lung cancer after platinum‐based chemoradiotherapy.
Takehiro Uemura, Kensuke Fukumitsu, Ken Maeno, Satoshi Fukuda, Tomohiro Onuki, Yoshihiro Kanemitsu, Tetsuya Oguri, Akio Niimi, Toyoaki Hida   +8 more
doaj   +1 more source

Impact of Renin‐Angiotensin System Inhibitors on Renal Function During Temporary Ileostomy Period in Rectal Cancer Patients: A Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen, Ryo Seishima, Masayoshi Monno, Satoru Morita, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa   +6 more
wiley   +1 more source

Exercise and Nutrition Prehabilitation Program During Preoperative Chemotherapy Followed by Esophagectomy in Older Patients With Esophageal Cancer: A Randomized Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
This prospective randomized trial evaluated whether prehabilitation, exercise and nutrition intervention, enhance skeletal muscle mass during neoadjuvant chemotherapy in older patients with esophageal cancer undergoing esophagectomy. We also investigated whether exercise alone was sufficient to increase skeletal muscle mass, and whether nutritional ...
Keijiro Sugimura, Takashi Kanemura, Tomohira Takeoka, Takahito Sugase, Norihiro Matsuura, Kazuyoshi Yamamoto, Masahiko Yano, Hiroshi Miyata   +7 more
wiley   +1 more source

Chemoradiotherapy for Head and Neck Cancer [PDF]

, 2023
Ida D’Onofrio, Valerio Nardone, Alfonso Reginelli, Salvatore Cappabianca   +3 more
openalex   +1 more source

Increase in Pancreatoduodenectomy Volume at Mid‐Volume Facilities in the United States: A National Cancer Database Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The annual number of pancreatoduodenectomies (PDs) in the United States has increased over the past decade, but the facility types driving this growth and whether outcomes have improved remain unclear. We aimed to identify characteristics of facilities with increasing PD volumes and assess national trends in centralization ...
Koichi Tomita, Naruhiko Ikoma
wiley   +1 more source

Clinical outcomes of chemoradiotherapy for locally recurrent rectal cancer

Radiation Oncology, 2011
Background To assess the clinical outcome of chemoradiotherapy with or without surgery for locally recurrent rectal cancer (LRRC) and to find useful and significant prognostic factors for a clinical situation.
Oh Jae Hwan, Choi Hyo Seong, Park Ji Won, Kim Sun Young, Kim Dae Yong, Lee Joo Ho, Chang Hee Jin, Kim Tae Hyun, Park Suk Won   +8 more
doaj   +1 more source

Enhancing Surgical Efficiency and Cost‐Effectiveness With TaTME‐Combined Robot‐Assisted Surgery for Lower Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Robot‐assisted rectal surgery (RAS) offers improved dexterity and visualization; however, the high cost of equipment and consumables remains a major challenge for hospital management. At our institution, we have adopted a combined approach using transanal total mesorectal excision (TaTME) for lower rectal cancers, aiming to shorten ...
Takeru Matsuda, Hiroshi Hasegawa, Yasunori Otowa, Masayuki Ando, Tomoaki Aoki, Yasufumi Koterazawa, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Yoshihiro Kakeji   +9 more
wiley   +1 more source