Results 51 to 60 of about 168,140 (338)

Exploring the Role of Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease

Pharmaceuticals
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder among the elderly population. The pathogenesis of PD encompasses genetic alterations, environmental factors, and age-related neurodegenerative processes.
Yiting Zhao, Man Lin, Fengguang Zhai, Jun Chen, Xiaofeng Jin   +4 more
doaj   +1 more source

A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer.

New England Journal of Medicine, 2004
BACKGROUND The effect of adjuvant treatment on survival in pancreatic cancer is unclear. We report the final results of the European Study Group for Pancreatic Cancer 1 Trial and update the interim results. METHODS In a multicenter trial using a two-by-
J. Neoptolemos, D. Stocken, H. Friess, C. Bassi, J. Dunn, H. Hickey, H. Beger, L. Fernández‐Cruz, C. Dervenis, F. Lacaine, M. Falconi, P. Pederzoli, Á. Pap, D. Spooner, D. Kerr, M. Büchler   +15 more
semanticscholar   +1 more source

The role of adjuvant chemotherapy for patients with resected pancreatic cancer: Systematic review of randomized controlled trials and meta-analysis [PDF]

, 2007
Background: In patients undergoing surgery for resectable pancreatic cancer prognosis still remains poor. The role of adjuvant treatment strategies (including chemotherapy and chemoradiotherapy) following resection of pancreatic cancer remains ...
Bakkevold KE, Berger AC, Blackstock AW, Cress RD, Donna Pauler Ankerst, Gastrointestinal Tumour Study Group, Hochster HS, Kalser MH, Khanna A, Knaebel HP, Kosuge T, Luttges J, Oettle H, Ozols RF, Peto R, Regine WF, Stefan Boeck, Volker Heinemann   +17 more
core   +1 more source

The Role of NF-κB/MIR155HG in Regulating the Stemness and Radioresistance in Breast Cancer Stem Cells

Frontiers in Bioscience-Landmark
Background: Breast cancer stem cells (BCSCs) are instrumental in treatment resistance, recurrence, and metastasis. The development of breast cancer and radiation sensitivity is intimately pertinent to long non-coding RNA (lncRNA). This
Yunbao Xu, Lu Yang, Guangming Li, Chuangzhou Rao   +3 more
doaj   +1 more source

Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial

JAMA Oncology, 2018
Importance Patients with borderline-resectable pancreatic ductal adenocarcinoma have historically poor outcomes with surgery followed by adjuvant chemotherapy. Evaluation of a total neoadjuvant approach with highly active therapy is warranted.
Janet E. Murphy, J. Wo, D. Ryan, Wenqing Jiang, B. Yeap, L. Drapek, L. Blaszkowsky, E. Kwak, Jill N. Allen, Jeffrey W. Clark, J. Faris, A. Zhu, L. Goyal, K. Lillemoe, T. Delaney, C. F. Fernandez-Del Castillo, C. Ferrone, T. Hong   +17 more
semanticscholar   +1 more source

Construction of a novel CD8T cell-related index for predicting clinical outcomes and immune landscape in ovarian cancer by combined single-cell and RNA-sequencing analysis

Discover Oncology
Background CD8T cells, also known as cytotoxic T lymphocytes, play a key role in the tumor immune microenvironment (TME) and immune response. The aim of this study was to explore the potential role of CD8T cell-associated biomarkers in predicting ...
Yu Zhang, Peng Wan, Liangliang Wang, Ruiping Ren   +3 more
doaj   +1 more source

Therapy-Related Acute Myeloid Leukemia 2 Months after Chemoradiotherapy for Esophageal Cancer: A Case Report

Case Reports in Oncology, 2020
Therapy-related acute myeloid leukemia (AML) is a rare but potentially fatal adverse event caused by chemotherapy or radiotherapy. Herein we report a patient diagnosed with therapy-related AML 2 months after chemoradiotherapy for esophageal cancer.
Shinya Hiraoka, Katsuyuki Sakanaka, Takahiro Iwai, Kota Fujii, Hiroyuki Inoo, Takashi Mizowaki   +5 more
doaj   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Predictive Value of Early Response to Chemoradiotherapy in Advanced Esophageal Squamous Cell Carcinoma by Diffusion-Weighted MR Imaging

Technology in Cancer Research & Treatment, 2020
Objective: To explore the value of diffusion-weighted imaging for early response detection of locally advanced esophageal squamous cell carcinoma with concurrent chemoradiotherapy. Methods: Fifty-five (42 males, 13 females) patients with locally advanced
Wei Chen MD, Ya-ting Wang MD, Lili Guo MD, Zhaohuan Zhu MD, Hai-fei Zhou MD, Genji Bai MD   +5 more
doaj   +1 more source

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]

, 2014
Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman, Araujo, Armitage, Baba, Bertagnolli, Curtis, Dhadda, Dhadda, Fadhil, Fadhil, Fearon, Fisher, Flyger, Fodde, Frei, Georgiades, Goh, Hadjihannas, Hawkins, Hedley, Heimann, Hutchins, Ilyas, Ingh, Jass, Karran, Kouri, Levitt, Lothe, Michelassi, Ormerod, Palles, Pino, Pritchard, Quirke, Rajagopalan, Ribic, Sieber, Silver, Suarez, Tang, The Cancer Genome Atlas Network, Thibodeau, Vecchio, Williams   +44 more
core   +2 more sources