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Correction to Favorable and poor prognosis B-cell precursor acute lymphoblastic leukemia subtypes reveal distinct leukemic cell properties when interacting with mesenchymal stem cells, differentially modifying their cell stemness and leukemia chemoresistance. [PDF]
J Cell Commun Signaleuropepmc +1 more source
Chemoresistance in Pancreatic Cancer [PDF]
International Journal of Molecular Sciences, 2019 Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC), ranks the fourth leading cause of cancer-related deaths in the western world. While the incidence of pancreatic cancer is displaying a rising tendency every year, the mortality rate has not decreased significantly because of late diagnosis, early metastasis, and limited
Siyuan Zeng, Marina Pottler, Bin Lan
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Molecular and Cellular Biochemistry, 2008
Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise of significant cell heterogeneity that contains a large number of multidrug resistant (MDR) phenotypes and cancer stem cells (CSCs), a combination that may contribute to the resistance to treatment.
Chen, Lu, Amal, Shervington
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Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise of significant cell heterogeneity that contains a large number of multidrug resistant (MDR) phenotypes and cancer stem cells (CSCs), a combination that may contribute to the resistance to treatment.
Chen, Lu, Amal, Shervington
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Extracellular Vesicles in Chemoresistance
2021Chemotherapy represents the current mainstay therapeutic approach for most types of cancer. Despite the development of targeted chemotherapeutic strategies, the efficacy of anti-cancer drugs is severely limited by the development of drug resistance. Multidrug resistance (MDR) consists of the simultaneous resistance to various unrelated cytotoxic drugs ...
Gabriele, De Rubis, Mary, Bebawy
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Fatty acids in cancer chemoresistance
Cancer Letters, 2023Despite the remarkable clinical success of immunotherapy and molecular targeted therapy in patients with advanced tumors, chemotherapy remains the most commonly used treatment for most tumor patients. Chemotherapy drugs effectively inhibit tumor cell proliferation and survival through their remarkable mechanisms.
Jiale Qin +6 more
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2013
Glioma remains one of the most aggressive and lethal form of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor with a median overall survival of just over 1 year. Most patients would die of tumour recurrences because of their tumours’ intrinsic or acquired resistance ...
Sun, S, Leung, GKK, Lee, D
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Glioma remains one of the most aggressive and lethal form of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor with a median overall survival of just over 1 year. Most patients would die of tumour recurrences because of their tumours’ intrinsic or acquired resistance ...
Sun, S, Leung, GKK, Lee, D
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Chemoresistance in falciparum malaria
Trends in Parasitology, 2003Tropical countries increasingly face the burden of drug resistance in Plasmodium falciparum infections. Malaria-related mortality of African children rises in contrast to the decline of the overall mortality of children under five years of age in sub-Saharan Africa within the past four decades.
Jürgen, May, Christian G, Meyer
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MicroRNAs in Pancreatic Cancer and Chemoresistance
Pancreas, 2021Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the leading malignancies affecting human health, largely because of the development of resistance to chemotherapy/radiotherapy. There are many mechanisms that mediate the development of drug resistance, such as the transport of antineoplastic agents into cells, shifts in energy ...
Yue, Pan +6 more
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