Results 131 to 140 of about 78,175 (168)
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Leishmaniasis: efflux pumps and chemoresistance
International Journal of Antimicrobial Agents, 2003Resistance of parasitic protozoa such as Leishmania to therapeutic drugs continues to escalate in developing countries. Treatment programs for human leishmaniasis are still based on pentavalent antimonials but resistance to these compounds has been a persistent problem.
Clara, Leandro, Lenea, Campino
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Molecular Bases of Chemoresistance in Cholangiocarcinoma
Current Drug Targets, 2017The multidrug resistance (MDR) phenotype accounts for the poor response of cholangiocarcinoma to available antitumor drugs. This is an important limitation to the use of pharmacological approaches, both as adjuvant therapies and for treating advanced CCA when surgical removal is not possible.
Jose J G, Marin +5 more
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Modulation of Apoptosis to Reverse Chemoresistance
2008Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and
Gil, Mor +2 more
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A snapshot of chemoresistance to PARP inhibitors
Trends in Pharmacological Sciences, 2012The exploitation of synthetic lethality in BRCA-deficient tumor carriers using potent inhibitors of the enzyme poly(ADP-ribose) polymerase (PARP)-1 has led to an enthusiastic response among basic scientists, oncologists and pharmaceutical companies. However, accumulating evidence demonstrates that resistance to these drugs develops in tumors in both ...
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A short update on cancer chemoresistance
Wiener Medizinische Wochenschrift, 2014Chemotherapeutic interventions in cancer patients are limited by the appearance of chemoresistance. For instance, advanced lung and ovarian cancer patients relapse invariably after few cycles of platinum-based chemotherapy. Disseminated tumors are characterized by genetic instability/heterogeneity, thus containing or generating a repertoire of ...
Gerhard, Hamilton, Barbara, Rath
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Autocrine mechanisms of cancer chemoresistance
Seminars in Cell & Developmental Biology, 2018An ever-increasing number of studies highlight the role of cancer secretome in the modification of tumour microenvironment and in the acquisition of cancer cell resistance to therapeutic drugs. The knowledge of the mechanisms underlying the relationship between cancer cell-secreted factors and chemoresistance is becoming fundamental for the ...
BUTERA, GIOVANNA +2 more
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Isolation of Chemoresistant Cell Subpopulations
2016Chemoresistance is a major challenge for cancer therapy and drives tumor relapse. The emergence, within the treated tumor mass, of specific cancer cell subpopulations endowed with high tolerance to the microenvironment stress induced by therapy is being growingly recognized as a mechanism of tumor progression. To obtain detailed information with regard
Claudia, Canino, Mario, Cioce
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Tunneling Nanotubes: Implications for Chemoresistance
Tunneling nanotubes (TNTs) are thin, membranous protrusions that connect cells and allow for the transfer of various molecules, including proteins, organelles, and genetic material. TNTs have been implicated in a wide range of biological processes, including intercellular communication, drug resistance, and viral transmission. In cancer, they have beenSanyukta, Padmanabhan +3 more
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