Results 151 to 160 of about 78,550 (267)

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Exosomal microRNAs as promising indicators of chemoresistance in lung cancer. [PDF]

Ann Med Surg (Lond)
Khalid H, Murtaza M, Amin MHJ.
europepmc   +1 more source

Correction to “POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation”

Advanced Science, EarlyView.
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Epigenetic regulation in cancer chemoresistance and combined therapeutic strategies. [PDF]

Front Cell Dev Biol
Jiang L, Yuan Y, Zhang D, Wang J, Jiang X, Shi Y.   +5 more
europepmc   +1 more source

Discriminating Chemoresistant and Chemosensitive Tubo‐Ovarian High‐Grade Serous Carcinoma Cells With Raman Microscopy

Journal of Raman Spectroscopy, EarlyView.
Confocal Raman microscopy combined with multivariate analysis distinguishes cisplatin‐resistant and ‐sensitive tubo‐ovarian high‐grade serous carcinoma cell lines. ABSTRACT Chemoresistance is a major obstacle to effective cancer treatment, particularly in tubo‐ovarian high‐grade serous carcinoma (HGSC), the most lethal gynaecological malignancy ...
Elina Harju, Parisa Movahedi, Teemu Tomberg, Sara J. Fraser‐Miller, Francesco Piga, Jukka Saarinen, Kathleen J. Sircombe, Jacopo Zini, Jukka Heikkonen, Anna Laury, Sarah Hook, Keith C. Gordon, Tapio Pahikkala, Clare J. Strachan   +13 more
wiley   +1 more source

KDM4B/DHX9 promotes chemoresistance in small-cell lung cancer through the MYCN-driven signaling pathway. [PDF]

Oncogene
Lyu Q, Liu H, Shen W, Lin Z, Zhang Y, Ying H, Long Q, Cao X, Zhang J, Shi J, Qiu Z.   +10 more
europepmc   +1 more source

Systematic Review and Meta‐Analysis of Resection Sequence in Synchronous Colorectal Liver Metastasis: Primary vs. Liver First

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background This present systematic review and meta‐analysis aims to compare overall survival (OS), disease‐free survival (DFS), morbidity and mortality outcomes in patients undergoing colorectal first (CRf) versus liver first (Lf) resections with synchronous colorectal liver metastases.
Sofoklis Mavrantonis, Omar Abou El‐Wafa, Sascha Vaghiri, Dimitrios Prassas   +3 more
wiley   +1 more source

Erratum: Biofunctional study on chemoresistance in esophageal squamous carcinoma cells induced by missense mutation of <i>NOTCH1 p.E450K</i>. [PDF]

J Thorac Dis
Editorial Office.
europepmc   +1 more source

PRDM1 Knockdown Promotes Ferroptosis and Sunitinib Sensitivity by Modulating the PI3K/Akt Signaling Through Inhibition of ESM1 Transcription in Renal Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Renal cell carcinoma (RCC) is a commonly occurring and considerable burden on public health. Although chemotherapy benefits patients with advanced RCC, sunitinib resistance leads to a poor prognosis. Ferroptosis is also involved in sunitinib resistance in RCC.
Yi‐Shuai Zhang, Xin‐Qi Pei, Ji‐Ping Sun, Chen‐Hui Ma, Xin‐Yang Wang, Xu‐Dong Li   +5 more
wiley   +1 more source