Results 161 to 170 of about 136,885 (362)

Supplementary Table 1 from Navitoclax (ABT-263) Reduces Bcl-x_L–Mediated Chemoresistance in Ovarian Cancer Models

, 2023
Maureen Wong, Nguyen Tan, Jiping Zha, Franklin Peale, Yue Peng, Wayne J. Fairbrother, Lisa D. Belmont   +6 more
openalex   +1 more source

Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA [PDF]

, 2023
Seyedeh Tayebeh Ahmadpour, Charlotte Orré, Priscila Bertevello, Delphine Mirebeau‐Prunier, Jean‐François Dumas, Valérie Desquiret‐Dumas   +5 more
openalex   +1 more source

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis

Advanced Science, EarlyView.
FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang   +11 more
wiley   +1 more source

Mechanisms of Resistance to Chemotherapy in Hypopharyngeal Carcinoma

Biomedicines
Hypopharyngeal carcinoma (HPC) represents the most prognostically unfavorable subtype among head and neck malignancies. Platinum-based neoadjuvant chemotherapy serves as a critical therapeutic approach for improving outcomes in hypopharyngeal carcinoma ...
Zhaoyue Lu, Zhiwei Qiang, Wenbin Lei, Zhimou Cai   +3 more
doaj   +1 more source

A novel approach for engineering DHCM/GelMA microgels: application in hepatocellular carcinoma cell encapsulation and chemoresistance research [PDF]

Dandan Zhou, Xiaoxiao Li, Wencun Liu, Mingjun Zhang, Ying Cheng, Zhousong Xu, Jian Gao, Yiyang Wang   +7 more
openalex   +1 more source

Data from Notch Signaling Activated by Replication Stress–Induced Expression of Midkine Drives Epithelial–Mesenchymal Transition and Chemoresistance in Pancreatic Cancer

, 2023
Cenap Güngör, Hilke Zander, Katharina E. Effenberger, Yogesh K. Vashist, Т. С. Калинина, Jakob R. Izbicki, Emre F. Yekebas, Maximilian Bockhorn   +7 more
openalex   +1 more source

The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome [PDF]

, 2020
Iolanda Ferro, Jacopo Gavini, Lisamaria Bracher, Marc Landolfo, Daniel Candinas, Deborah Stroka, Norbert Polacek   +6 more
openalex   +1 more source

Overcoming chemoresistance [PDF]

Nature Reviews Drug Discovery, 2019
openaire   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation

Cell Death Discovery
Osteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we
Zhiwei Tao, Pingan Zou, Zhengxu Yang, Tao Xiong, Zhi Deng, Qincan Chen   +5 more
doaj   +1 more source