Results 191 to 200 of about 64,721 (205)

Cell Biology of Cancer Peritoneal Metastasis: Multiclonal Seeding and Peritoneal Tumor Microenvironment

Cancer Science, Volume 116, Issue 5, Page 1171-1180, May 2025.
We summarize recent findings on the cell biological aspects of peritoneal metastasis and potential therapeutic target molecules. We focus on the molecular mechanisms underlying cluster/spheroid formation in multiclonal peritoneal metastasis and cancer–stroma interactions within the peritoneal tumor microenvironment. ABSTRACT Peritoneal metastasis, also
Hideki Yamaguchi, Makoto Miyazaki
wiley   +1 more source

HSP27/IL-6 axis promotes OSCC chemoresistance, invasion and migration by orchestrating macrophages via a positive feedback loop. [PDF]

Cell Biol Toxicol
Qi Y, Cao J, Jiang M, Lin Y, Li W, Li B.
europepmc   +1 more source

Insights From Nonsense‐Mediated mRNA Decay for Prognosis in Homologous Recombination‐Deficient Ovarian Cancer

Cancer Science, Volume 116, Issue 5, Page 1449-1463, May 2025.
In this study, an NMD prediction algorithm and an optimized 8 NMD‐linked gene prognostic index model were generated by machine learning algorithms in ovarian cancer. Our results provide a new perspective based on NMD status and cell cycle pathways to discriminate subtypes of gBRCA and HRD patients.
Lei Han, Jialing Liu, Runjiao Zhang, Yanan Cheng, Li Dong, Lijuan Wei, Juntian Liu, Ke Wang, Jinpu Yu   +8 more
wiley   +1 more source

Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma. [PDF]

World J Gastroenterol
Liang YB, Chen XM, Luo WL, Ke Y.
europepmc   +1 more source

Comprehensive characterization of MCL‐1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes

International Journal of Cancer, Volume 156, Issue 8, Page 1583-1593, 15 April 2025.
What's new? MCL‐1, an anti‐apoptotic protein required for intestinal homeostasis, has been associated with chemoresistance in colorectal cancer. This study provides novel insights into the molecular profile and tumor microenvironment of colorectal cancer according to MCL‐1 mRNA expression.
Pooja Mittal, Francesca Battaglin, Yasmine Baca, Joanne Xiu, Alex Farrell, Shivani Soni, Jae Ho Lo, Lesly Torres‐Gonzalez, Sandra Algaze, Priya Jayachandran, Karam Ashouri, Alexandra Wong, Wu Zhang, Jian Yu, Lin Zhang, Benjamin A. Weinberg, Emil Lou, Anthony F. Shields, Richard M. Goldberg, John L. Marshall, Sanjay Goel, Indrakant K. Singh, Heinz‐Josef Lenz   +22 more
wiley   +1 more source

Targeting FOXP1 phase separation in small cell lung cancer mechanisms of chemotherapy resistance. [PDF]

Commun Biol
Tang Y, Niu Y, Chen Y, Zhou X, Hu Y, Sun L, Xiong Y, Xu Y, Wang Q, Wang Y, Guo L.   +10 more
europepmc   +1 more source

Effects of Cholesterol on the Breast Cancer Resistance Protein: Studies through the Synthesis and Biological Evaluation of Chemical Tools

ChemMedChem, Volume 20, Issue 8, April 14, 2025.
This study explores the role of cholesterol in the regulation of the efflux pump ABCG2. Substrates and inhibitors of ABCG2, cholesterol linked to fluorescents probes were synthesized and tested to investigate the influence of cholesterol on ABCG2 inhibition and to track cholesterol trafficking on cells.
Ingrid Fatima Zattoni, Bruna Estelita Rugisnk, Isadora da Silva Zanzarini, Alan Guilherme Gonçalves, Vivian Rotuno Moure, Glaucio Valdameri, Ahcène Boumendjel   +6 more
wiley   +1 more source

MiR-769-5p of macrophage exosomes induced by GRP78 promotes stemness and chemoresistance in colorectal cancer. [PDF]

Cell Death Dis
Tian J, Zhang L, La X, Fan X, Li Z.
europepmc   +1 more source

MiCK: a database of gut microbial genes linked with chemoresistance in cancer patients. [PDF]

Database (Oxford)
Shahzaib M, Muaz M, Zubair MH, Kayani MUR.   +3 more
europepmc   +1 more source

CD44v6-mediated regulation of gastric cancer stem cells: a potential therapeutic target. [PDF]

Clin Exp Med
Chen H, Ling R, Lai J, Liu Z, Wang Z, Yang H, Kong Y.   +6 more
europepmc   +1 more source