Results 261 to 270 of about 136,885 (362)

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Inflammatory milieu and role of epigenetic modifications in high-grade serous ovarian cancer. [PDF]

Clin Epigenetics
Pradhan S, Kabekkodu SP, Eswaran S, Kumar NAN, Upadhya D, Chakrabarty S, Devi V.   +6 more
europepmc   +1 more source

Roles of ERα and ERβ in estrogen-induced DDP chemoresistance in non-small cell lung cancer

, 2016
Nina Yu, L. Dou, Yan Li, Lei Deng, Xueqiang Wei, Yun Guo   +5 more
openalex   +1 more source

Mitochondrial Transfer in the Tumor Microenvironment

Cancer Science, EarlyView.
Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae, Takamasa Ishino, Yosuke Togashi   +2 more
wiley   +1 more source

<i>ICAM2</i> loss drives 5-fluorouracil resistance <i>via</i> TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer. [PDF]

World J Gastroenterol
Tang XC, Chen ZJ, Chen CY, Qiu J, Huang JT, Tan RC, Li WY, Chen H, Yang ZL.   +8 more
europepmc   +1 more source

Circ‐0030167/IGF2BP1 Induces Mitophagy‐Mediated Ferroptosis via HMOX1 mRNA Stabilization in Pancreatic Cancer

Cancer Science, EarlyView.
Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao, Xihao Yao, Jingjing Lu, Qiyang Chen, Zhiwei Wang, Xiaohong Li, Yuhua Lu   +6 more
wiley   +1 more source

Correction to Favorable and poor prognosis B-cell precursor acute lymphoblastic leukemia subtypes reveal distinct leukemic cell properties when interacting with mesenchymal stem cells, differentially modifying their cell stemness and leukemia chemoresistance. [PDF]

J Cell Commun Signal
europepmc   +1 more source

SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence [PDF]

Zhang Xianhong, Yue Gao, Yu Zhang, Zhang Yichen, Yufei Chen, Pei Xinke, Zhang Jinhui, Yiqi Wang, Yitian Du, Hao Shuailin, Ting Ni   +10 more
openalex   +1 more source

Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression

Cancer Science, EarlyView.
Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley   +1 more source

Evaluating temozolomide for pediatric adamantinomatous craniopharyngiomas using microspheroid-based drug screening. [PDF]

Childs Nerv Syst
Cavalheiro S, Pavon LF, de Farias CB, da Silva NS, Nascimento FB, Sibov TT, Rodrigues JB, Dastoli PA, Suzuki FS, Watanabe RA, Kim IHT, Lichtenfels M, da Silva CA, Cappellano A, da Costa MDS.   +14 more
europepmc   +1 more source