Animal Models and Experimental Medicine, EarlyView.Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage +4 more
wiley +1 more source
Induction of arthritis by purified cell-derived chemotactic factor: role of chemotaxis and vascular permeability. [PDF]
, 1977 Isaias Spilberg +2 more
openalex +1 more source
Demonstration of macrophage chemotactic factors in the aqueous humor during experimental immunogenic uveitis in rabbits [PDF]
, 1976 Neal A. Sher +3 more
openalex +1 more source
Research progress on the treatment of bullous pemphigoid with Dupilumab
Pifu-xingbing zhenliaoxue zazhiIn recent years, there have been many reports on the use of Dupilumab in the treatment of bullous pemphigoid. Dupilumab specifically binds to the subunit alpha of interleukin 4 receptor (IL-4Rα), blocking the signal transduction of interleukin (IL)-4 and
LUO Xiaojia +3 more
doaj +1 more source
Gout and NLRP3 Inflammasome Biology
Arthritis &Rheumatology, EarlyView.This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley +1 more source
Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. [PDF]
, 1988 Yuji Yamaguchi +9 more
openalex +1 more source
Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor
Cancer Communications, EarlyView.Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai +6 more
wiley +1 more source
Monokine-induced gene expression of a human endothelial cell-derived neutrophil chemotactic factor [PDF]
, 1988 Robert M. Strieter +3 more
openalex +1 more source
Cancer Communications, EarlyView.Abstract Background Eps15 homology domain (EHD) proteins, including EHD1 to EHD4, play vital roles in tumor progression. In this study, we aimed to investigate which specific EHD proteins, if any, are implicated in tumor immune evasion and immunotherapy response.
Fanglin Tian +11 more
wiley +1 more source
NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES
ChemMedChem, Accepted Article.Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti +4 more
wiley +1 more source