Results 171 to 180 of about 133,222 (232)

Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression

MedComm, Volume 6, Issue 6, June 2025.
Clinical cohort analyses in COPD patients demonstrated lncRNA IL6‐AS1 overexpression inversely correlating with lung function. AAV‐mediated transgenic models and coculture system revealed fibroblast‐derived IL6‐AS1 stabilizes S100A9 through exosomal transfer to macrophages, promoting TLR4/AGER binding and NF‐κB‐driven inflammatory amplification ...
Erkang Yi, Xiaoyu Wang, Yu Liu, Zihui Wang, Ge Bai, Xinyue Mei, Fan Wu, Chengshu Xie, QiYang Li, Weitao Cao, Huahua Xu, Xinyuan Liu, Jieda Cui, Haiqing Li, Ruiting Sun, Xinru Ran, Wei Hong, Zhishan Deng, Bing Li, Yumin Zhou, Pixin Ran   +20 more
wiley   +1 more source

Decoupling chemical and mechanical signaling in colorectal cancer cell migration. [PDF]

Sci Rep
Tetrick MG, Emon MAB, Doha U, Marcellus M, Symanski J, Ramanathan V, Saif MTA, Murphy CJ.   +7 more
europepmc   +1 more source

Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application

MedComm, Volume 6, Issue 6, June 2025.
Before the cancer cells arrive to the lung through blood vessels, these cancer cells secreted specific factors for two main purposes: first, to recruit bone marrow‐derived cells; and second, to regulate the activation of target cells. Additionally, the unique structure of the lungs provides a comfortable environment. Consequently, the formation of lung
Chenghao Cao, Di Lu, Huigang Li, Shen Pan, Jianyong Zhuo, Zuyuan Lin, Chiyu He, Peiru Zhang, Songmin Ying, Xuyong Wei, Shusen Zheng, Zhe Yang, Xiao Xu   +12 more
wiley   +1 more source

The Therapeutic Potential of Theobromine in Obesity: A Comprehensive Review. [PDF]

Nutr Rev
Tuğal Aslan D, Göktaş Z.
europepmc   +1 more source

Clinical C3 Inhibition With AMY‐101 Reveals Novel Insights Into IL‐8‐Driven Inflammation in COVID‐19

Immunology, Volume 175, Issue 3, Page 288-291, July 2025.
Christina Antoniadou, Anastasia‐Maria Natsi, Dimitrios C. Mastellos, Evangelos Papadimitriou, Efstratios Gavriilidis, Victoria Tsironidou, Vasileios Papadopoulos, Evgenios Eftalitsidis, Μaria Κoffa, Markus Huber‐Lang, Antonio M. Risitano, Despina Yancopoulou, Georgios Germanidis, Konstantinos Ritis, John D. Lambris, Panagiotis Skendros   +15 more
wiley   +1 more source

Unlocking T‐Cell Plasticity in the Tumor Microenvironment: Implications for Cancer Progression and Therapeutic Strategies

MedComm – Oncology, Volume 4, Issue 2, June 2025.
The tumor microenvironment (TME) shapes T‐cell plasticity, influencing cancer progression and therapeutic outcomes. Here, we summarize the phenotypic transitions and spatial distribution of T cells within the TME, highlighting their dual roles in therapeutic efficacy and resistance.
Xiao‐Hong Ding, Xue‐Pei Li, Fenfang Chen, Han Wang, Yi‐Zhou Jiang   +4 more
wiley   +1 more source

Features of the monocyte inflammatory response in patients with premature coronary artery disease. [PDF]

Biophys Rep
Blokhina T, Kirichenko T, Markina Y, Khovantseva U, Melnikov I, Guseva O, Bazanovich S, Kozlov S, Orekhov A.   +8 more
europepmc   +1 more source

STAB1 Promotes Acute Myeloid Leukemia Progression by Activating the IKK/NF‐κB Pathway and Increasing M2 Macrophage Polarization

Cancer Science, Volume 116, Issue 6, Page 1508-1521, June 2025.
In this study, we explored the effects of silenced STAB1 expression in AML cells on the polarization of M2‐like macrophages, as well as the involvement of nuclear factor‐kappa B (NF‐κB) signaling pathways in the pro‐oncogenic roles of STAB1. By investigating the expression pattern of STAB1 along with its regulatory mechanisms in AML patients, we aimed ...
Jiaxiu Yin, Jing Luo, Lan Wang, Lanxiang Liu, Lin Liu   +4 more
wiley   +1 more source

Xanthatin nanocrystals exert anti-inflammatory properties against TNFα-primed 2D monolayers and in 3D spheroids of human HT29 colorectal cancer cells. [PDF]

Discov Nano
Berenguer Roque A, Zgheib A, Salomon-Izquierdo S, Manso Peña A, Osoria Alfonso LA, Piloto-Ferrer J, Annabi B.   +6 more
europepmc   +1 more source

Impact of Smoking on Macrophage‐Related Chemokines During Initial Peri‐Implantitis: A Prospective Cohort Study

Clinical Implant Dentistry and Related Research, Volume 27, Issue 3, June 2025.
ABSTRACT Objectives Smoking disrupts macrophage chemokine response and delays healing. This study aims to investigate the effect of smoking on peri‐implant crevicular fluid (PICF) levels of macrophage‐related chemokines, C‐C motif chemokine ligand 2 (CCL‐2), C‐C motif chemokine ligand 8 (CCL‐8), C‐X‐C motif chemokine ligand 9 (CXCL‐9), and C‐C motif ...
Buse Naz Buyukakcali Altay, Zeynep Turgut Cankaya, Mustafa Yilmaz, Mervi Gürsoy, Aysen Bodur, Ulvi Kahraman Gürsoy   +5 more
wiley   +1 more source