Results 61 to 70 of about 77,751 (291)

Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite

Engineering, 2017
Stem cell homing, namely the recruitment of mesenchymal stem cells (MSCs) to injured tissues, is highly effective for bone regeneration in vivo. In order to explore whether the incorporation of mimetic peptide sequences on magnesium-doped (Mg-doped ...
Alessandro Pistone, Daniela Iannazzo, Claudia Espro, Signorino Galvagno, Anna Tampieri, Monica Montesi, Silvia Panseri, Monica Sandri   +7 more
doaj   +1 more source

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

Chemotactic factor receptor modulation and cytoskeletal structures [PDF]

Infection and Immunity, 1981
The microfilament-disrupting agents cytochalasins A, B, and D were shown to impair the binding of the chemotactic factors [3H]formylmethionylleucylphenylalanine and 125 I-labeled crystal-induced chemotactic factor to their neutrophil receptor. Scatchard plot analysis revealed a decrease of the available binding sites in the cytochalasin B-treated cells.
J Mehta, I Spilberg
openaire   +3 more sources

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

Advanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti, Xinyuan Jiang, Xiuying Chen, Mingshu Xiao, Sujing Jiang, Yun Xu, Peng Xiao, Jiangnan Zhao, Kaiyue Zhang, Mengshu Li, Kai Wang   +14 more
wiley   +1 more source

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer

Frontiers in Endocrinology, 2020
A hallmark of inflammatory responses is leukocyte mobilization, which is mediated by pathogen and host released chemotactic factors that activate Gi-protein-coupled seven-transmembrane receptors (GPCRs) on host cell surface. Formylpeptide receptors (FPRs,
Weiwei Liang, Weiwei Liang, Keqiang Chen, Wanghua Gong, Teizo Yoshimura, Yingying Le, Ying Wang, Ji Ming Wang   +7 more
doaj   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Study of urinary monocytic chemotactic factor

Perm Medical Journal, 2020
The review presents the data on clinical diagnostic value of studying one of the components of urinary proteome - macrophage chemotactic protein -1 (MCP-1). Along with the general characteristics of MCP-1, there are given the data on changes in its concentration regarding various diseases of the urinary system.
A. M. Ivanov, D. Yu. Sosnin, K. R. Galkovich   +2 more
openaire   +3 more sources

A Two‐Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto‐Aerotaxis

Advanced Science, EarlyView.
Magnetotactic bacteria align with Earth's magnetic field, helping them migrate toward low‐oxygen environments. This study reveals how Magnetospirillum gryphiswaldense uses a specialized flavin adenine dinucleotide (FAD)‐dependent chemoreceptor, composed of two interacting proteins, for precise navigation in oxygen gradients.
Julian Herz, Carina Weigel, Leonie Scheder, Raz Zarivach, Itay Algov, Yonatan Chemla, Felix Popp, Cornelius Riese, Mohammad A. Charsooghi, Lital Alfonta, Michael M. Meijler, Dirk Schüler, Damien Faivre, Daniel Pfeiffer   +13 more
wiley   +1 more source

Chemokinetic and Chemotactic Factors in Psoriasis Scale Extracts

Journal of Investigative Dermatology, 1978
Soluble solutions of psoriasis scale were prepared by extracting scales in 6 m urea and removing urea by dialysis. Extracts were tested for chemokinetic and chemotactic activity for human polymorphonuclear leukocytes and mononuclear cells in vitro using the migration under agarose assay.
Robert D. Nelson, Mark V. Dahl, William E. Lindroos   +2 more
openaire   +3 more sources

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source