Results 161 to 170 of about 71,798 (273)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Functional Interactions Between Recombinant Serum Amyloid A1 (SAA1) and Chemokines in Leukocyte Recruitment. [PDF]

Int J Mol Sci
Van Damme J, Struyf S, Proost P, Opdenakker G, Gouwy M.   +4 more
europepmc   +1 more source

Inhibitory Effects of 3′,4′‐Dihydroxyflavonol in a Rabbit Model of Minimally Invasive Bleb Surgery With PreserFlo MicroShunt

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background The success of minimally invasive bleb surgery (MIBS) such as the PreserFlo MicroShunt (PFMS) is limited by post‐operative bleb fibrosis. Current clinical practice prescribes the use of off‐label cytotoxic antimetabolites such as Mitomycin C (MMC) as antifibrotic therapy.
Zoe Pasvanis, Roy C. K. Kong, Elsa C. Chan, Jennifer C. Fan Gaskin   +3 more
wiley   +1 more source

Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis. [PDF]

Commun Biol
Sun J, Sun Y, Guo D, Ye H, Huang Q, Zhou H, Li C, Liao M, You Y, Shang H, Zhou P, Wu D, Witowski J, Hu Z, Peng H.   +14 more
europepmc   +1 more source

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei, Hanzhang Wu, Ningjian Wang, Jiahao Zhu, Ranjit Mohan Anjana, Aleksandr V. Sokolov, Helgi B. Schiöth, Viswanathan Mohan, Xiao Tan   +8 more
wiley   +1 more source

Inflammation and epithelial–mesenchymal transition in a CFTR‐depleted human bronchial epithelial cell line revealed by proteomics and human organ‐on‐a‐chip

The FEBS Journal, EarlyView.
Proteomic analysis of cystic fibrosis transmembrane conductance regulator knockout (CFTR‐KO) clones of 16HBE14o‐ cells showed altered pathways linked to inflammation, polymorphonuclear leukocyte (neutrophil) recruitment, and epithelial–mesenchymal transition.
Domenico Mattoscio, Luis A. Baeza, Haiqing Bai, Tommaso Colangelo, Simone Castagnozzi, Marta Marzotto, Maria Concetta Cufaro, Virginia Lotti, Yu‐Chieh Yuan, Matteo Mucci, Longlong Si, Mariachiara Zuccarini, Maria Tredicine, Simona D'Orazio, Damiana Pieragostino, Piero Del Boccio, Claudio Sorio, Marco Trerotola, Mario Romano, Roberto Plebani   +19 more
wiley   +1 more source

Neutrophils at the Crossroads of Inflammatory Bowel Disease and Atherosclerosis: A State-of-the-Art Review. [PDF]

Cells
Genkel V, Zaripova Y, Kuznetsova A, Sluchanko A, Minasova A, Zotova M, Saenko A, Savochkina A, Dolgushina A.   +8 more
europepmc   +1 more source

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

The FEBS Journal, EarlyView.
Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos   +6 more
wiley   +1 more source

The Ragulator complex and lysosomal calcium release are crucial for cell migration. [PDF]

Life Sci Alliance
Jo T, Tsujimoto K, Nakatani T, Nagira D, Muto Y, Hirayama T, Konaka H, Okada M, Takamatsu H, Kumanogoh A.   +9 more
europepmc   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source