Results 81 to 90 of about 65,117 (210)

Modeling emergent tissue organization involving high-speed migrating cells in a flow equilibrium

, 2007
There is increasing interest in the analysis of biological tissue, its organization and its dynamics with the help of mathematical models. In the ideal case emergent properties on the tissue scale can be derived from the cellular scale. However, this has
Beyer, Tilo, Meyer-Hermann, Michael
core   +1 more source

Microglial IKKβ Alters Central and Peripheral Immune Activity at Distinct Time Points After Spinal Cord Injury

Glia, EarlyView.
Microglial NF‐κB signaling increases M1‐like spinal microglia over time after spinal cord injury. Microglial NF‐κB signaling broadly affects gene expression in spinal cord. Microglial NF‐κB signaling modulates splenocytes acutely after spinal cord injury.
Micaela L. O'Reilly, Mariah J. Wulf, Theresa M. Connors, Ying Jin, Frank Bearoff, Julien Bouyer, Sandhya Kortagere, John R. Bethea, Veronica J. Tom   +8 more
wiley   +1 more source

Role of Macrophage TLR4 Expression in the Immunopathogenesis of Severe Aplastic Anemia

Journal of Clinical Laboratory Analysis, EarlyView.
This study found that the high expression of TLR4 in macrophages of SAA patients was positively correlated with the sepsis level, and inhibition of TLR4 expression could reduce the macrophage sepsis level and the killing effect of CD8+ T cells, thus alleviating the over‐activated cellular immune response in SAA patients.
Mengran Gao, Xiaorui Meng, Yi Cui, Ling Deng, Xinrui Zhang, Chunyan Liu, Rong Fu   +6 more
wiley   +1 more source

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Med Research, EarlyView.
Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin   +9 more
wiley   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Influence of 17 beta-estradiol, progesterone, and dexamethasone on diapedesis and viability of bovine blood polymorphonuclear leukocytes [PDF]

, 2004
The aim of the current study was to investigate whether polymorphonuclear leukocyte (PMN) diapedesis and viability are influenced by steroid hormones.
Burvenich, Christian, Duchateau, Luc, Lamote, Inge, Meyer, Evelyne   +3 more
core   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, EarlyView.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source

A Single‐Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging

Aging Cell, EarlyView.
This study utilized single‐cell RNA sequencing to analyze immune cells in 33 human testis samples (ages 21–69). We found age‐related alterations in monocytes and MRC1hi TRM, with shifts in phagocytosis, cytokine, and antigen presentation, contributing to low‐grade inflammation in aging. These findings provide insights into immune aging in human testis.
Qiaoling Jiang, Lina Cui, Xichen Nie, Hui Cai, Wenxiu Zhang, Xiaojian Lu, Yifei Guo, James M. Hotaling, Bradley R. Cairns, Xiaoyan Wang, Jingtao Guo   +10 more
wiley   +1 more source

Chemotaxis by polymorphonuclear leukocytes [PDF]

The Journal of cell biology, 1978
openaire   +3 more sources

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Aging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu   +8 more
wiley   +1 more source