Results 211 to 220 of about 277,155 (334)

Degradation of Nonribosomal Peptide Synthetase Megasynthetases SrfAA and SrfAB by Acyldepsipeptide‐Activated ClpP in Bacillus Subtilis

ChemBioChem, EarlyView.
FtsZ is the only target protein that has been biochemically confirmed to be hydrolyzed both in vitro and in bacterial cells. Coupled with activity‐based protein profiling of nonribosomal peptide synthetases, the ClpP‐ADEP1 proteolytic complex that degrades the surfactin synthetases SrfAA and SrfAB in cell lysates and bacterial cells is demonstrated ...
Fumihiro Ishikawa, Chiharu Uchida, Rina Ohnishi, Taketo Imai, Genzoh Tanabe   +4 more
wiley   +1 more source

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

Journal of Leukocyte Biology, 2015
Wenjuan Xuan, Q. Qu, B. Zheng, S. Xiong, G. Fan   +4 more
semanticscholar   +1 more source

Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans. [PDF]

Nat Commun
Xue W, Chen Y, Lei Z, Wang Y, Liu J, Wen X, Xu F, Chen P, Wu Z, Jin YN, Yu YV.   +10 more
europepmc   +1 more source

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

Cytoskeleton, EarlyView.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker, Karen Baker, Marina Ezcurra, Philippe P. Laissue, Lin Wang, Michael A. Geeves, Jennifer M. Tullet, Daniel P. Mulvihill   +7 more
wiley   +1 more source

Insights into Chemoreceptor MCP2201-Sensing D-Malate. [PDF]

Int J Mol Sci
Cui R, Li J, Hong Y, Guo L, Wang YH, Bai YF, Li DF.   +6 more
europepmc   +1 more source

Synthesis and 64Cu‐Radiolabeling Strategies of Small Organic Radioconjugates Based on the AMD070 Scaffold

ChemMedChem, Accepted Article.
CXCR4 is a transmembrane receptor overexpressed in a large variety of cancer cells. In addition to classical antibody‐ and peptide‐targeting for the development of Positron Emission Tomography (PET) radiopharmaceuticals, this receptor possesses a range of small organic inhibitors that can be exploited. These are based mainly on nitrogen‐rich scaffolds,
Marie M Le Roy, Patricia Le Saëc, Michel Chérel, Alain Faivre-Chauvet, Raphaël Tripier, Thibault TROADEC   +5 more
wiley   +1 more source

Alkane degradation mechanism of <i>Mixta calida</i> HXX308 isolated from sediment of the Mariana Trench. [PDF]

Front Microbiol
Yang Y, He X, Zhang Y, Zhang XH.
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Endotoxin-induced autocrine ATP signaling inhibits neutrophil chemotaxis through enhancing myosin light chain phosphorylation

Proceedings of the National Academy of Sciences of the United States of America, 2017
Xu Wang, W. Qin, Xiaohan Xu, Yuyun Xiong, Yisen Zhang, Huafeng Zhang, Bingwei Sun   +6 more
semanticscholar   +1 more source

High-throughput assessment of the behavioral responses to toxic organic solvents in Caenorhabditis elegans. [PDF]

PLoS One
Tomioka M.
europepmc   +1 more source