Results 271 to 280 of about 442,266 (316)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Salt chemotaxis and its plasticity in hermaphroditic nematodes. [PDF]

MicroPubl Biol
Matsumura A, Komachiya Y, Sugiyama A, Tanuma M, Ohno H.   +4 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

On collective behavior in <i>C. elegans</i>. [PDF]

Front Neurorobot
Antonic N, Vellinger A, Tuci E.
europepmc   +1 more source

Antibacterial Micro/Nanorobots: Innovations, Challenges, and Future Perspectives in Combatting Infection

Nano Select, EarlyView.
Antibacterial micro/nanorobots (MNRs) represent a breakthrough in antibacterial therapy, making precise delivery of drugs to the infection site. This review systematically summarizes the material composition, actuation, and applications of MNRs in combating biofilms and drug‐resistant infections while emphasizing the existing challenges of ...
Yichao Chen, Chenlin Jiang, Chuxie Zhang, Wenqing He, Changshun Hou   +4 more
wiley   +1 more source

The CCL17/CCL22-CCR4 Axis in Pain Pathogenesis: A Comprehensive Review of Immune-Mediated Mechanisms and Therapeutic Opportunities. [PDF]

Mol Neurobiol
Hasheminia A, Mann S, Liblik K, El-Diasty M.   +3 more
europepmc   +1 more source

Papillary renal cell carcinoma with high‐ABCC2 shows an immune‐evasive profile associated with favorable response to immunotherapy

The Journal of Pathology, EarlyView.
Abstract The use of immune checkpoint inhibitors is a promising therapeutic strategy for metastatic papillary renal cell carcinoma (PRCC); however, predictive biomarkers remain limited. PRCCs with high ABCC2 expression represent an aggressive subset frequently associated with metastasis.
Vincent Francis Castillo, Abraam Zakhary, Fabio Rotondo, Caterina Di Ciano‐Oliveira, Malek Hamdani, Emelyn Adona, Theodorus van der Kwast, Kiril Trpkov, Rola Saleeb   +8 more
wiley   +1 more source

Beyond anemia: unraveling neutrophil defects and infection susceptibility in β-Thalassemia. [PDF]

Blood Res
Asadov C, Aliyeva G.
europepmc   +1 more source

Interleukin‐8 Overexpressing Collagen Microgel‐Based Cellular Microtissue Accelerates the Healing of Diabetic Foot Ulcers

Small, EarlyView.
Collagen microgels (CMGs) incubated with cells self‐assemble into CMG‐based cellular microtissues (CCMs), enhancing cell adhesion and upregulating IL‐8 expression. A combinatorial strategy that integrates the CMG platform with IL‐8 overexpression promotes cell proliferation, migration, angiogenesis, and survival, thereby accelerating diabetic wound ...
Haeun Chung, Won Young Jang, Jung‐Kyun Choi, Sang‐Heon Kim   +3 more
wiley   +1 more source

The effects of interleukin-6-receptor inhibition on monocytes in STEMI: a substudy of the ASSAIL-MI trial. [PDF]

EBioMedicine
Huse C, Murphy SL, Yang K, Balzer NR, Stokke MK, Anstensrud AK, Bjerkeli V, Rentz T, Jha PK, Ugland HK, Michelsen AE, Ueland T, Holm S, Tøllefsen IM, Bendz B, Kleveland O, Andersen GØ, Gullestad L, Louch WE, Woxholt S, Osnes L, Broch K, Ulas T, Aukrust P, Libby P, Halvorsen B, Dahl TB.   +26 more
europepmc   +1 more source