Results 151 to 160 of about 800,324 (296)
Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy
Advanced Science, EarlyView.Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie +10 morewiley +1 more sourceMAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression
Advanced Science, EarlyView.Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He +12 morewiley +1 more sourceImpact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era
Annals of Gastroenterological Surgery, EarlyView.Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama +7 morewiley +1 more sourceInteraction Between Operator and Assistant Certification Is Associated With Local Recurrence After Laparoscopic Rectal Cancer Surgery: An Ancillary Analysis of the EnSSURE Study
Annals of Gastroenterological Surgery, EarlyView.A significant synergistic interaction between operator and assistant certification was associated with a lower risk of local recurrence after laparoscopic rectal cancer surgery. Patients treated by both ESSQS‐qualified operators and assistants had the lowest risk of local recurrence, whereas a single qualification alone was not associated with a ...Yusuke Sakimura, Hiroyuki Bando, Koya Hida, Tatsunari Fukuoka, Tohru Funakoshi, Fuminori Teraishi, Kay Uehara, Yuji Inoue, Nobuaki Suzuki, Nobuki Ichikawa, Hiroaki Iijima, Akinobu Taketomi, Yoshiharu Sakai, Takeshi Naitoh, Ichiro Takemasa, the EnSSURE study group collaboratives within the Japan Society of Laparoscopic Colorectal Surgery, Akinobu Furutani, Akiyoshi Kanazawa, Akiyoshi Noda, Atsushi Ishibe, Chikayoshi Tani, Daisuke Yamamoto, Fumihiko Fujita, Fumio Ishida, Fumitaka Asahara, Heita Ozawa, Hideaki Karasawa, Hideki Osawa, Hiroaki Nagano, Hiroaki Takeshita, Hirofumi Ota, Hirokazu Suwa, Hiroki Ochiai, Hiroomi Ogawa, Hiroshi Saeki, Hirotoshi Hasegawa, Hisanaga Horie, Hisashi Nagahara, Jun Watanabe, Kaori Hayashibara, Kazuhiro Takehara, Ken Kojo, Ken Okamoto, Kenichiro Saito, Koji Ikeda, Koji Munakata, Koki Otsuka, Koki Goto, Kunihiko Nagakari, Mamoru Uemura, Manabu Shimomura, Manabu Shiozawa, Manabu Takata, Manabu Yamamoto, Masaaki Ito, Masafumi Inomata, Masahiko Watanabe, Masakatsu Numata, Masashi Miguchi, Masatsune Shibutani, Mayumi Ozawa, Mitsuhisa Takatsuki, Naoya Aisu, Naruhiko Sawada, Ryo Ikeshima, Ryo Inada, Ryuichi Oshima, Satoshi Maruyama, Shigehiro Kojima, Shigeki Yamaguchi, Shigenori Homma, Shiki Fujino, Shinichiro Mori, Shinobu Ohnuma, Sho Takeda, Shota Aoyama, Shuji Saito, Shunpei Mukai, Shusaku Takahashi, Takahiro Sasaki, Takahiro Yamanashi, Takeru Matsuda, Takuya Miura, Tatsunori Ono, Tatsuya Kinjo, Tatsuya Shonaka, Teni Godai, Tomohiro Adachi, Tomohiro Yamaguchi, Tomohisa Furuhata, Tomonori Akagi, Toshimoto Kimura, Toshisada Aiba, Toshiya Nagasaki, Toshiyoshi Fujiwara, Tsukasa Shimamura, Tsunekazu Mizushima, Yasuhito Iseki, Yasuo Sumi, Yasushi Rino, Yasuyuki Kamada, Yohei Kurose, Yoshiaki Kita, Yoshihiro Kakeji, Yoshihiro Takashima, Yoshihito Ide, Yoshinori Munemoto, Yoshito Akagi, Yoshiyuki Ishii, Yuki Kiyozumi, Yukihito Kokuba, Yukitoshi Todate, Yusuke Sakimura, Yusuke Shimodaira, Yusuke Suwa +114 morewiley +1 more sourceAdjuvant chemotherapy for patients with rectal cancer
, 2013 A new Cochrane meta-analysis evaluated adjuvant chemotherapy (5-fluorouracil (5FU)-based, not modern combination chemotherapy) in almost 10,000 patients with rectal cancer and showed a 17% reduction in mortality corresponding well to the efficacy ...Qvortrup, Camilla, Mortensen, John Pløen, Pfeiffer, Per; id_orcid +2 morecore +1 more sourceOne‐Year Changes in Frailty Components After Curative Minimally Invasive Surgery for Colorectal Cancer in Older Patients
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background
Frailty predicts outcomes after colorectal cancer surgery, but postoperative changes remain unclear. We previously reported improvement in FRAIL Scale‐based frail/pre‐frail status 1 year after curative minimally invasive surgery (MIS).Hajime Ushigome, Takuya Suzuki, Shunsuke Hayakawa, Akira Kato, Yushi Yamakawa, Kenta Saito, Hiroyuki Sagawa, Ryo Ogawa, Hiroki Takahashi, Shuji Takiguchi +9 morewiley +1 more sourceCD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
Annals of Gastroenterological Surgery, EarlyView.CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe +10 morewiley +1 more sourceCorrection: Revisiting metformin as a chemotherapy adjuvant: a systematic review and meta-analysis based on recent randomized-controlled trials. [PDF]
Front OncolSaddiq BWB, Morad AS, Khan TN, Alshowaikhat JJ, Alsharari JN, Bajri RO, AlZayer MJ, Mouazen SM, Abutaleb MA, Radi S, Alwafi H. +10 moreeuropepmc +1 more sourceBiological Resectability in Colorectal Liver Metastases: A Nomogram‐Based Continuous Risk Model to Define Borderline Disease
Annals of Gastroenterological Surgery, EarlyView.KRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.Yuzo Umeda, Toshiharu Mitsuhashi, Tomokazu Fuji, Toru Kojima, Takeshi Koujima, Tatsuo Matsuda, Daisuke Satoh, Masaru Inagaki, Kosei Takagi, Toshiyoshi Fujiwara +9 morewiley +1 more sourceRevisiting metformin as a chemotherapy adjuvant: a systematic review and meta-analysis based on recent randomized-controlled trials. [PDF]
Front OncolBin Saddiq BW, Morad AS, Khan TN, Alshowaikhat JJ, Alsharari JN, Bajri RO, AlZayer MJ, Mouazen SM, Abutaleb MA, Radi S, Alwafi H. +10 moreeuropepmc +1 more source
