Results 21 to 30 of about 747,376 (295)

Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy : results from the BIG 02-98 phase III trial [PDF]

, 2012
Introduction: Pre-clinical data suggest p53-dependent anthracycline-induced apoptosis and p53-independent taxane activity. However, dedicated clinical research has not defined a predictive role for TP53 gene mutations. The aim of the current study was to
Viale, Giuseppe, Leo, Angelo Di, Olivier, Magali, Smoth, Ke-Seay, Crown, John, Piccart-Gebhart, Martine, Buyse, Marc, Hainaut, Pierre, Azambuja, Evandro De, Falagan-Lotsch, Priscila, Quinaux, Emmanuel, Dolci, M Stella, Larsimont, Denis, Oakman, Catherine, Francis, Prudence A, Fernández-Cuesta, Lynnette, Dell'orto, Patrizia   +16 more
core   +5 more sources

Adjuvant chemotherapy for medulloblastoma [PDF]

Cancer, 1985
The use of adjuvant chemotherapy for cerebellar medulloblastoma is controversial. Twenty-one children and adolescents were treated with adjuvant low-dose cyclophosphamide and vincristine following surgery and radiotherapy. With a mean observation period of 6 years, the disease-free survival is 81%.
S, McIntosh, M, Chen, P A, Sartain, C, Duncan, R, Fishburn, E H, Klatskin, A D, Schwartz, J L, Venes   +7 more
openaire   +2 more sources

Improved overall survival is associated with adjuvant chemotherapy after definitive concurrent chemoradiotherapy for N3 nasopharyngeal cancer

Scientific Reports, 2022
Concurrent chemoradiotherapy is the established treatment for locally advanced nasopharyngeal carcinoma (NPC). However, there is no evidence supporting routine adjuvant chemotherapy. We aimed to demonstrate the effect of adjuvant chemotherapy on survival
Mu-Hung Tsai, Shang-Yin Wu, Hsi-Huei Lu, Tsung Yu, Sen-Tien Tsai, Yuan-Hua Wu   +5 more
doaj   +1 more source

Differences in the performance of adjuvant chemotherapy between hemodialysis and nonhemodialysis patients

Cancer Medicine, 2023
Background The survival of hemodialysis (HD) patients with cancer is poor, which may be caused by undertreatment due to renal dysfunction. Particularly, adjuvant chemotherapy after surgery may be considered optional because of its preventive nature. This
Taisuke Ishii, Tomone Watanabe, Takahiro Higashi   +2 more
doaj   +1 more source

Adjuvant chemotherapy and survival outcomes in rectal cancer patients with good response (ypT0-2N0) after neoadjuvant chemoradiotherapy and surgery: A retrospective nationwide analysis

Frontiers in Oncology, 2022
BackgroundFor rectal cancer, it remains unclear how to incorporate tumor response to neoadjuvant chemoradiotherapy (nCRT) when deciding whether to give adjuvant chemotherapy.
Yu-Hsuan Kuo, Yu-Hsuan Kuo, Yun-Tzu Lin, Chung-Han Ho, Chung-Han Ho, Chia-Lin Chou, Chia-Lin Chou, Li-Chin Cheng, Chia-Jen Tsai, Wei-Ju Hong, Yi-Chen Chen, Ching-Chieh Yang, Ching-Chieh Yang   +12 more
doaj   +1 more source

Impact of adjuvant chemotherapy on T1N0M0 breast cancer patients: a propensity score matching study based on SEER database and external cohort

BMC Cancer, 2022
Background There is no clear consensus on the benefits of adjuvant chemotherapy for tumor-node-metastasis (TNM) stage T1 (T1N0M0) breast cancer (BC). Our study investigated the effects of adjuvant chemotherapy on T1N0M0 BC patients.
Kaiwen Shen, Longdi Yao, Jingyuan Zhu, Ximing Gu, Jie Wang, Wei Qian, Zhijian Zheng, Deyuan Fu, Song Wu   +8 more
doaj   +1 more source

Diabetes alone should not be a reason for withholding adjuvant chemotherapy for stage III colon cancer [PDF]

, 2011
Background: With increasing prevalence of diabetes mellitus and colon cancer, the number of patients suffering from both diseases is growing, and physicians are being faced with complicated treatment decisions.
Wouter M. W. Dercksen, Extermann, Martine, Harm R. Haak, Janssen-Heijnen, Maryska L.G., van de Schans, Saskia A.M., Haak, Harm R., Dercksen, Wouter M.W., Maren A. van Waalwijk, Martine Extermann, van Waalwijk, Maren A., Saskia A. M. van de Schans, Maryska L. G. Janssen-Heijnen   +11 more
core   +1 more source

Adjuvant chemotherapy for locally advanced upper tract urothelial carcinoma: updated results of the Seoul National university hospital experience

International Brazilian Journal of Urology, 2015
Objectives: The objective of this study was to update the long-term outcome in the treatment of locally advanced upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU) regarding the role of adjuvant chemotherapy.
Hyung Suk Kim, Joong Sub Lee, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku   +5 more
doaj   +1 more source

Clinical feasibility of (neo)adjuvant taxane-based chemotherapy in older patients : analysis of >4,500 patients from four German randomized breast cancer trials [PDF]

, 2008
Introduction: Despite the fact that people older than 65 years of age have the highest incidence of developing breast cancer, these patients are excluded from clinical trials in most cases.
Kümmel, Sherko, Sibylle Loibl, Gunter von Minckwitz, Kuemmel, Sherko, Valentina Nekljudova, Marion Kiechle, Elling, Dirk, Holm Eggemann, Harald Sommer, Janni, Wolfgang, Sommer, Harald, Wolfgang Janni, Loibl, Sibylle, Nadia Harbeck, Manfred Kaufmann, Harbeck, Nadia, Nekljudova, Valentina, Minckwitz, Gunter von, Sherko Kümmel, Kiechle, Marion, Kaufmann, Manfred, Eggemann, Holm, Dirk Elling   +22 more
core   +2 more sources

Comparison of the effects of adjuvant concurrent chemoradiotherapy and chemotherapy for resected biliary tract cancer

BMC Gastroenterology, 2020
Background Biliary tract cancers (BTC) have a poor prognosis even after curative resection because of frequent local and distant recurrences. Therefore, the importance of adjuvant therapy in BTC has been advocated to improve outcomes. However, the choice
Hyera Kim, Mi Hwa Heo, Jin Young Kim
doaj   +1 more source