Results 61 to 70 of about 212,420 (268)

Combination Chemotherapy Optimization with Discrete Dosing [PDF]

arXiv, 2021
Chemotherapy is one of the primary modalities of cancer treatment. Chemotherapy drug administration is a complex problem that often requires expensive clinical trials to evaluate potential regimens. One way to alleviate this burden and better inform future trials is to build reliable models for drug administration.
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Reevaluation of regional lymph nodes in patients with pancreatic ductal adenocarcinoma in the pancreatic body and tail

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 147-156, January 2023., 2023
This study indicated that LN of both the CA and SMA systems should be dissected in patients with Pb‐PDAC. However, only those around the SPA and splenic hilus should be dissected routinely in those with Pt‐PDAC. Abstract Introduction In patients with pancreatic ductal adenocarcinoma (PDAC) in the pancreatic body (Pb) and tail (Pt), the appropriate area
Yuki Matsui, Daisuke Hashimoto, Sohei Satoi, Tomohisa Yamamoto, So Yamaki, Mitsuaki Ishida, Satoshi Hirooka, Tsukasa Ikeura, Mitsugu Sekimoto   +8 more
wiley   +1 more source

Prognostic nutritional index is an independent risk factor for continuing S-1 adjuvant chemotherapy in patients with pancreatic cancer who received neoadjuvant chemotherapy and surgical resection

BMC Cancer
Purpose Reports on the association of perioperative nutritional and inflammatory status with the clinical course of adjuvant chemotherapy did not include neoadjuvant chemotherapy.
Shinnosuke Kawahara, Toru Aoyama, Masaaki Murakawa, Rei Kanemoto, Daishi Takahashi, Yuto Kamioka, Itaru Hashimoto, Yukio Maezawa, Satoshi Kobayashi, Makoto Ueno, Naoto Yamamoto, Takashi Oshima, Norio Yukawa, Yasushi Rino, Aya Saito, Soichiro Morinaga   +15 more
doaj   +1 more source

Preoperative SCC-Ag as a predictive marker for the use of adjuvant chemotherapy in cervical squamous cell carcinoma with intermediate-risk factors

BMC Cancer, 2020
Background For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them.
Hong-tao Guo, Xue-han Bi, Ting Lei, Xiao Lv, Guang Yao, Yao Chen, Chang Liu   +6 more
doaj   +1 more source

Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating [PDF]

, 2016
Magnetic hyperthermia is a new type of cancer treatment designed for overcoming resistance to chemotherapy during the treatment of solid, inaccessible human tumors. The main challenge of this technology is increasing the local tumoral temperature with minimal side effects on the surrounding healthy tissue.
arxiv   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Prognostic factors in conversion surgery following nab‐paclitaxel with gemcitabine and subsequent chemoradiotherapy for unresectable locally advanced pancreatic cancer: Results of a dual‐center study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 157-166, January 2023., 2023
For radical surgery after induction gemcitabine along with nab‐paclitaxel and subsequent chemoradiotherapy for unresectable locally advanced pancreatic ductal adenocarcinoma, CA19‐9 normalization and maintenance of good nutritional status during treatment until surgery were important for prolonged prognosis.
Takamichi Igarashi, Suguru Yamada, Yui Hoshino, Kenta Murotani, Hayato Baba, Hideki Takami, Isaku Yoshioka, Kazuto Shibuya, Yasuhiro Kodera, Tsutomu Fujii   +9 more
wiley   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Do postoperative infectious complications really affect long‐term survival in colorectal cancer surgery? A multicenter retrospective cohort study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 110-120, January 2023., 2023
This multicenter retrospective cohort study suggested that postoperative infection (PI) after curative colorectal surgery (CRC) is associated with impaired oncological outcomes. Strategies to prevent PI and implement appropriate postoperative treatment may improve the quality of care and oncological outcomes in patients undergoing curative CRC surgery.
Akihisa Matsuda, Hiroshi Maruyama, Shinji Akagi, Toru Inoue, Kenichiro Uemura, Minako Kobayashi, Hisanori Shiomi, Manabu Watanabe, Hiroki Arai, Yutaka Kojima, Yusuke Mizuuchi, Hajime Yokomizo, Yuji Toiyama, Toru Miyake, Yasuyuki Yokoyama, Kei Ishimaru, Shigeru Takeda, Yoshihisa Yaguchi, Yuko Kitagawa   +18 more
wiley   +1 more source