Results 51 to 60 of about 392,226 (299)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Evolving roles of systemic therapy in hepatocellular carcinoma: neoadjuvant and adjuvant strategies [PDF]

Journal of Liver Cancer
Surgical resection for early-stage hepatocellular carcinoma (HCC) provides the potential for long-term survival but recurrence rates within 5 years were up to 70%. Thus, neoadjuvant or adjuvant strategies can be important to improve outcomes.
Ho Soo Chun, Minjong Lee, Tae Hun Kim
doaj   +1 more source

Quality of life changes during adjuvant chemotherapy in patients with colon cancer [PDF]

Korean Journal of Clinical Oncology, 2016
Purpose: The survival of advanced colon cancer patients has increased due to the development of surgical techniques and adjuvant chemotherapy. The administration of adjuvant chemotherapy after curative resection is generally accepted as a standard of ...
Seo Hee Lee, Taek-Gu Lee, Moo Jun Baek, Jang Jin Kim, Sung-Su Park, Sang-Jeon Lee   +5 more
doaj   +1 more source

Duration of adjuvant chemotherapy for stage III colon cancer [PDF]

, 2018
BACKGROUND Since 2004, a regimen of 6 months of treatment with oxaliplatin plus a fluoropyrimidine has been standard adjuvant therapy in patients with stage III colon cancer.
Andre, Thierry, Boukovinas, Ioannis, Grothey, Axel, Iveson, Timothy, Kerr, Rachel, Labianca, Roberto, Meyerhardt, Jeffrey A., Meyers, Jeffrey P., Niedzwiecki, Donna, Paul, James, Renfro, Lindsay A., Sargent, Daniel J., Saunders, Mark, Shi, Qian, Shields, Anthony F., Sobrero, Alberto F., Souglakos, John, Taieb, Julien, Torri, Valter, Vernerey, Dewi, Watanabe, Toshiaki, Yamanaka, Takeharu, Yoshino, Takayuki   +22 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Prognostic nutritional index is an independent risk factor for continuing S-1 adjuvant chemotherapy in patients with pancreatic cancer who received neoadjuvant chemotherapy and surgical resection

BMC Cancer
Purpose Reports on the association of perioperative nutritional and inflammatory status with the clinical course of adjuvant chemotherapy did not include neoadjuvant chemotherapy.
Shinnosuke Kawahara, Toru Aoyama, Masaaki Murakawa, Rei Kanemoto, Daishi Takahashi, Yuto Kamioka, Itaru Hashimoto, Yukio Maezawa, Satoshi Kobayashi, Makoto Ueno, Naoto Yamamoto, Takashi Oshima, Norio Yukawa, Yasushi Rino, Aya Saito, Soichiro Morinaga   +15 more
doaj   +1 more source

Recent Advances in Adjuvant Therapy for Non–Small-Cell Lung Cancer [PDF]

Tuberculosis and Respiratory Diseases
After the successful development of targeted therapy and immunotherapy for the treatment of advanced-stage non-small cell lung cancer (NSCLC), these innovative treatment options are rapidly being applied in the adjuvant setting for early-stage NSCLC ...
Mi-Hyun Kim, Soo Han Kim, Min Ki Lee, Jung Seop Eom   +3 more
doaj   +1 more source

Adjuvant Chemotherapy in Patients with Node-Negative Non-Small Cell Lung Cancer with Satellite Pulmonary Nodules in the Same Lobe

Journal of Chest Surgery, 2022
Background: According to the eighth TNM (tumor-node-metastasis) staging system, the presence of separate tumor nodules in the same lobe is designated as a T3 descriptor.
Jiyoun Park, Junghee Lee, Yeong Jeong Jeon, Sumin Shin, Jong Ho Cho, Hong-Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim   +9 more
doaj   +1 more source

The benefits and harms of adjuvant chemotherapy for non-small cell lung cancer in patients with major comorbidities: A simulation study.

PLoS ONE, 2022
BackgroundRandomized controlled trials (RCTs) have demonstrated a survival benefit for adjuvant platinum-based chemotherapy after resection of locoregional non-small cell lung cancer (NSCLC).
Amanda Leiter, Chung Yin Kong, Michael K Gould, Minal S Kale, Rajwanth R Veluswamy, Cardinale B Smith, Grace Mhango, Brian Z Huang, Juan P Wisnivesky, Keith Sigel   +9 more
doaj   +1 more source

First-line therapy in HER2 positive metastatic breast cancer. Is the mosaic fully completed or are we missing additional pieces? [PDF]

, 2016
The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outcomes for women with early-stage and advanced ...
Cognetti F., Fabi A., Malaguti P., Vari S.   +3 more
core   +2 more sources