Metronomic chemotherapy preserves quality of life ensuring efficacy in elderly advanced non small cell lung cancer patients [PDF]
, 2016 Metastatic non small cell lung cancers (NSCLC) are diseases with poor prognosis and platinum-based doublet chemotherapy still remains their standard cure.
DE IULIIS, Francesca +5 more
core +1 more source
Pseudomonas aeruginosa: the history of one of the most successful nosocomial pathogens in Russian hospitals [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2018 Pseudomonas aeruginosa is recognized as one of the six most important pathogens in terms of antimicrobial resistance («ESKAPE» pathogens), and included by WHO in the group of microorganisms for which the need for development of new antimicrobial agents ...
Skleenova E.Yu. +5 more
doaj
Dosimetric advantage of volumetric modulated arc therapy in the treatment of intraocular cancer
Radiation Oncology, 2017 Objective The purpose of this study is to investigate the dosimetric advantages of volumetric modulated arc therapy (VMAT) in the treatment of intraocular cancer by comparing it directly with three-dimensional conformal radiotherapy (CRT) and intensity ...
Zhenxiang Deng +7 more
doaj +1 more source
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer.
New England Journal of Medicine, 2003 BACKGROUND Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer.
A. Forastiere +14 more
semanticscholar +1 more source
Nature Communications, 2019 The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due to the emergence of resistance. Here, the authors develop a new ROS1/NTRK inhibitor, DS-6051b, which overcomes crizotinib resistance in preclinical models.
Ryohei Katayama +23 more
doaj +1 more source
Investigating the development of chemotherapeutic drug resistance in cancer: A multiscale computational study [PDF]
arXiv, 2014 Chemotherapy is one of the most important therapeutic options used to treat human cancers, either alone or in combination with radiation therapy and surgery. Recent studies have indicated that intra-tumoural heterogeneity has a significant role in driving resistance to chemotherapy in many human malignancies.
arxiv
Polo like kinase 2 tumour suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer [PDF]
, 2012 The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers. The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian ...
Blagden, S. +6 more
core +1 more source
Microbiology Spectrum, 2017 ABSTRACT The management of tuberculosis (TB) can be a challenging process that has implications both for the affected patient and public health. Effective anti-TB chemotherapy both cures and renders the patient noncontagious. Biological factors specific to M.
Thomas E. Dobbs, Risa M. Webb
openaire +2 more sources
Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution. [PDF]
, 2019 Background:Dedifferentiated chondrosarcomas (DDCSs) are highly malignant tumors with a dismal prognosis and present a significant challenge in clinical management.
Chebib, Ivan +10 more
core +1 more source
Journal of Clinical Oncology, 2018 Purpose To provide guidance regarding the practical assessment and management of vulnerabilities in older patients undergoing chemotherapy. Methods An Expert Panel was convened to develop clinical practice guideline recommendations based on a systematic ...
S. Mohile +16 more
semanticscholar +1 more source